ArticleOdontology2025
Zinc nanoparticles induced eggshell collagen membrane used for guided bone regeneration: A novel approach in rabbit models.
Article in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The potential of eggshell membrane in bone regeneration: a scoping review of applications and advances.The Saudi dental journal · 2026Review
- Biological and toxicological evaluation of chicken eggshell membrane for guided bone regeneration: AnBioinformation · 2026Article
- Comparative evaluation of the effectiveness of a novel composite bone substitute synthesized from eggshell-derived hydroxyapatite and fish collagen in bone regeneration of critical-sized calvarial defects in Wistar rats.Frontiers in dental medicine · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional methods of guided bone regeneration (GBR) in bone tissue engineering frequently encounter challenges in attaining adequate antibacterial and osteogenic qualities owing to intrinsic limits. The purpose of this preclinical study was to assess the effectiveness of two distinct membranes, Healiguide® and a unique GBR membrane produced from eggshell membranes (ESM), in combination with bone graft replacement in animal models. The objective of this study was to evaluate the efficacy of a new guided bone regeneration membrane developed from eggshell membrane that incorporates zinc nanoparticles for the regeneration of bone tissue in rabbit models. Groups A (no membrane), B (new ESM GBR membrane), and C (Healiguide® membrane) were assigned to three groups, with eight male New Zealand rabbits weighing two-three kilograms each. Standardized surgical procedures were implemented, and histological analysis along with radiographic examination was used for follow-up assessments six and 12 weeks after surgery. Radiographic examination and histological sectioning revealed differences in bone density and quality between the groups. Group B showed the highest level of bone regeneration, followed by Groups C and A. Statistical analysis confirmed a significant difference between the groups (p < 0.05). The eggshell membrane showed encouraging results in the enhancement of bone regeneration and integration in rabbit models. These results suggest its potential as a viable alternative to GBR in bone tissue engineering, with promising prospects for improving clinical outcomes. However, additional studies and clinical trials are required to confirm its safety and effectiveness for medical use.
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Registered trials
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