Evidence map›Paper›PMID 39668272›Full record

ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2025

Total reversal of the pulmonary circulation (RPC) induced by peripheral cannulation for veno-arterial ECMO in a patient with aortic and mitral valve insufficiency: a case report.

Johannes Heymer, Daniel Bent, Daniel Raepple

Abstract readCase Reports
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In one paragraph

Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Johannes HeymerInternal Medicine Intensive Care, Klinikum Stuttgart, Kriegsbergstrasse 60, 70174, Stuttgart, Germany.
Daniel BentInternal Medicine Intensive Care, Klinikum Stuttgart, Kriegsbergstrasse 60, 70174, Stuttgart, Germany.
Daniel RaeppleInternal Medicine Intensive Care, Klinikum Stuttgart, Kriegsbergstrasse 60, 70174, Stuttgart, Germany. d.raepple@klinikum-stuttgart.de.ORCID http://orcid.org/0000-0002-3515-2990

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report details a rare instance of total reversal of the pulmonary circulation (RPC) in a 56-year-old male patient on veno-arterial extracorporeal membrane oxygenation (V-A ECMO) during emergency cardiopulmonary resuscitation (eCPR) following a myocardial infarction and cardiac arrest. Previously unrecognized aortic and mitral valve regurgitations, along with V-A ECMO flow, resulted in severe pulmonary edema. We describe how pulmonary artery cannulation and modifying the ECMO circuit to veno-pulmonary arterial-arterial (VPa-A) ECMO successfully alleviated the severe pulmonary edema but may have caused reversal of the pulmonary circulation (RPC). To our knowledge, this is the first reported case of this phenomenon in a human.

Indexed as

Aortic Valve InsufficiencyCatheterization, PeripheralExtracorporeal Membrane OxygenationMitral Valve InsufficiencyPulmonary CirculationPulmonary EdemaCardiopulmonary ResuscitationHeart ArrestHumansMaleMiddle AgedAortic valve regurgitationMitral valve regurgitationPulmonary edemaReverse pulmonary blood flowV-A ECMO

Identifiers

PMID39668272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.