Evidence map›Paper›PMID 39668209›Full record

ArticleNature methods2025

MouseGoggles: an immersive virtual reality headset for mouse neuroscience and behavior.

Matthew Isaacson, Hongyu Chang, Laura Berkowitz, Rick Zirkel, Yusol Park, Danyu Hu, Ian Ellwood, Chris B Schaffer

Abstract read
In one paragraph

Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Neurophotonics · 2025
    Article
  6. Year in review 2024.Nature methods · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew Isaacson *Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. mdi22@cornell.edu.ORCID http://orcid.org/0000-0001-8797-0090
Hongyu Chang *Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0009-0001-2710-7081
Laura BerkowitzMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Rick ZirkelMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-1744-0785
Yusol ParkDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Danyu HuMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Ian EllwoodDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Chris B SchafferMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-7800-9596

Funding

Metabolic and neural activity normalization by cerebral blood flow increase in AD/ADRD modelsR01AG081931 · NIA · CORNELL UNIVERSITY · PI CHRIS B SCHAFFER · 2023 to 2026
$4.5M
STALLED CAPILLARY FLOW: A NOVEL MECHANISM FOR HYPOPERFUSION IN ALZHEIMER DISEASER01AG049952 · NIA · CORNELL UNIVERSITY · PI NISHIMURA, NOZOMI, SCHAFFER, CHRIS B · 2015 to 2025
$3.5M
Supplement: Stalled capillary flow affects protein clearance by modulating interstitial fluid flowRF1AG049952 · NIA · CORNELL UNIVERSITY · PI NISHIMURA, NOZOMI, SCHAFFER, CHRIS B · 2021 to 2022
$2.6M
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 30285BrightFocus Foundation (BrightFocus) A2023006FNational Science Foundation (NSF) Graduate Research FellowshipNIA NIH HHS R01 AG049952NIA NIH HHS R01 AG081931NIA NIH HHS RF1 AG049952
6 · The paper itself

Abstract

Small-animal virtual reality (VR) systems have become invaluable tools in neuroscience for studying complex behavior during head-fixed neural recording, but they lag behind commercial human VR systems in terms of miniaturization, immersivity and advanced features such as eye tracking. Here we present MouseGoggles, a miniature VR headset for head-fixed mice that delivers independent, binocular visual stimulation over a wide field of view while enabling eye tracking and pupillometry in VR. Neural recordings in the visual cortex validate the quality of image presentation, while hippocampal recordings, associative reward learning and innate fear responses to virtual looming stimuli demonstrate an immersive VR experience. Our open-source system's simplicity and compact size will enable the broader adoption of VR methods in neuroscience.

Indexed as

Behavior, AnimalNeurosciencesVirtual RealityAnimalsEye-Tracking TechnologyHippocampusMaleMiceMice, Inbred C57BLPhotic StimulationVisual Cortex

Identifiers

PMID39668209
PMCPMC11810773

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.