Evidence map›Paper›PMID 39668167›Full record

ReviewNature reviews. Disease primers2024

Ectopic pregnancy.

Krystle Y Chong, Liesl de Waard, Munira Oza, Madelon van Wely, Davor Jurkovic, Maria Memtsa, Andrea Woolner, Ben W Mol

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Krystle Y ChongDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-8558-0491
Liesl de WaardDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Munira OzaThe Ectopic Pregnancy Trust, London, UK.ORCID http://orcid.org/0000-0002-2180-7896
Madelon van WelyCentre for Reproductive Medicine, Amsterdam Reproduction & Development Research Institute, Amsterdam UMC, Amsterdam, The Netherlands.
Davor JurkovicElizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Maria MemtsaElizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.
Andrea WoolnerAberdeen Centre for Women's Health Research, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Ben W MolDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia. ben.mol@monash.edu.ORCID http://orcid.org/0000-0001-8337-550X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectopic pregnancy, defined as the implantation of a developing pregnancy outside of the endometrial cavity of the uterus, is the leading cause of early-pregnancy maternal mortality. The majority of ectopic pregnancies implant in a fallopian tube. Acute complications may include rupture of the fallopian tube or rupture of ectopic pregnancy, haemorrhage and hypovolaemic shock, or occur secondary to treatments such as emergency surgery or blood transfusions, and ultimately increase the risk of maternal death. After ectopic pregnancy, patients may experience ongoing morbidity, including chronic pain, infertility and psychological distress. Assessment of ectopic pregnancy should focus on prompt diagnosis based on clinical and investigative findings but should also reflect a patient-centred approach with acknowledgement of potential psychological distress associated with pregnancy loss and reduced future fertility. Over the last four decades, the foundations of non-invasive diagnosis have been transvaginal sonography and serum β-human chorionic gonadotropin, with diagnostic laparoscopy as a confirmatory test if surgical treatment is planned. Once diagnosed, ectopic pregnancy can be managed expectantly, treated medically with methotrexate or managed surgically. Future fertility is an important but often overlooked aspect in the management of ectopic pregnancy.

Indexed as

Pregnancy, EctopicFemaleHumansMethotrexatePregnancyMethotrexate

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.