Trial reportBMJ open respiratory research2024
Ultrasound-guided transbronchial cryobiopsy of mediastinal and hilar lesions: a multicenter pragmatic cohort study with real-world evidence.
Trial report in BMJ open respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Diagnostic Yield of EBUS Mediastinal Cryobiopsy Versus TBNA in Suspected Lymphoproliferative Disorders: A Prospective Multicentre Study.Respirology (Carlton, Vic.) · 2026Article
- Enhancing Diagnostic Yield: The Role of Endobronchial Ultrasound-Guided Cryobiopsy in the Evaluation of Mediastinal Lymphadenopathy.CHEST pulmonary · 2026Article
- Indications, techniques, and safety of cryotherapy and cryobiopsy via flexible bronchoscopy in pediatric patients.Annals of the American Thoracic Society · 2026Observational
- Diagnostic value of EBUS-guided transbronchial mediastinal cryobiopsyERJ open research · 2026Article
- Revisiting the reported superiority of endobronchial ultrasound (EBUS)-guided transbronchial mediastinal cryobiopsy over EBUS-guided transbronchial needle aspiration in sarcoidosis.ERJ open research · 2026Article
- Diagnostic yield and feasibility of EBUS-guided cautery-assisted transbronchial forceps biopsy for suspected benign mediastinal and hilar lymphadenopathy: a prospective self-controlled pilot study.BMC pulmonary medicine · 2026Article
- Superior Diagnostic Yield of EBUS-Guided Cryobiopsy over Needle Aspiration in Isolated, Mass-Negative Mediastinal Lymphadenopathy: A Prospective Within-Patient Study.Diagnostics (Basel, Switzerland) · 2026Article
- Molecular Analysis of EBUS-TBNA Samples for Nodal Staging in Non-Small Cell Lung Cancer.Cancers · 2026Review
- Comparative Efficacy of Transbronchial Needle Aspiration and Cryobiopsies in Thoracic Disorders: A Systematic Review and Meta-Analysis for Optimal Diagnostic Efficacy.Life (Basel, Switzerland) · 2026Review
- Diagnostic yield and histopathological assessment of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: a prospective comparison of two tunnelling approaches.ERJ open research · 2026Article
- Scoping out sarcoidosis: the evolving role of bronchoscopy.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- The granulomatous pulmonary nodules induced by tislelizumab in advanced squamous NSCLC: a case report with challenging differential diagnosis.Translational lung cancer research · 2025Article
- Transbronchial Mediastinal Cryobiopsy Guided by Endobronchial Ultrasound in Addition to Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Ilo-Mediastinal Lymphadenopathy Without Obvious Primary Lung Neoplastic Lesion: A Prospective Multicenter Study.Journal of clinical medicine · 2025Article
- Article
- Mediastinal staging of nonsmall cell lung cancer: what's new?Breathe (Sheffield, England) · 2025Review
- Needle tract seeding after endobronchial ultrasound-guided intranodal forceps biopsy and cryobiopsy: a case report.Translational lung cancer research · 2025Article
- Updates in Diagnostic Tools for ILD.Journal of clinical medicine · 2025Review
- Safety and efficacy of endobronchial ultrasound-guided transbronchial biopsy of intrathoracic lymphadenopathy.Frontiers in medicine · 2025Article
- EBUS-guided Cryobiopsy-Proven Anthracotic Mediastinal Lymph Node Mimicking Malignancy on FDG PET-CT: A Case Report.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited data exist on the reliability, efficacy and safety of ultrasound-guided transbronchial cryobiopsy for suspicious mediastinal and hilar lesions. This study shares findings from implementing this method and compares the results with those of the standard endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).
methodsPatients undergoing diagnostic bronchoscopy for mediastinal or hilar lesions in four Swiss centres were included. The study aims to assess the diagnostic yield and safety of EBUS-guided cryobiopsy compared with EBUS-TBNA. Tunnelling to the target lesion was performed using an electric needle knife (70.8%), a 19 G- (12.4%) or a 22 G needle (16.8%). Cryobiopsies were obtained with a freezing time of 4-7 s (18.2% with a 1.7 mm probe) or 6-10 s (81.8% with a 1.1 mm probe).
resultsAltogether, 137 patients were enrolled with a median follow-up of 89 days. The overall diagnostic yield was 56.2% for EBUS-TBNA and 91.2% for cryobiopsies (p<0.001). Cryobiopsies increased the diagnostic yield for benign disorders (+28.5%), uncommon tumours (+5.9%) and other metastatic cancer (+0.6%), but not for lung cancer (+0%). For lung cancer (n=27), immunohistochemistry was obtainable in 40.7% of EBUS-TBNA (median of 3 probes [IQR 3 to 3]), significantly lower than cryobiopsy's 88.9% yield (median of 4 probes [IQR 3 to 5]) (p<0.001). Adverse events were found in 23.4% of participants; 10.2% had mild to moderate bleeding, 0.7% had pneumonia, and 0.7% (one) of patients had pneumothorax following pneumomediastinum. No deaths or mediastinum infections were observed.
conclusionCryobiopsy of mediastinal and hilar lesions improves the diagnostic yield compared with EBUS-TBNA while maintaining a favourable safety profile.
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