Evidence map›Paper›PMID 39668062›Full record

ReviewTrends in cognitive sciences2025

Models of human hippocampal specialization: a look at the electrophysiological evidence.

Anne Freelin, Cody Wolfe, Bradley Lega

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anne FreelinDepartment of Neuroscience, University of Texas Southwestern, Dallas, TX, 75390, USA.
Cody WolfeDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, 75390, USA.
Bradley LegaDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, 75390, USA. Electronic address: bradley.lega@utsouthwestern.edu.

Funding

Deciphering the genomic mechanisms underlying the physiology of human brain stimulationRF1NS126143 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI KONOPKA, GENEVIEVE, LEGA, BRADLEY C · 2022 to 2024
$4.0M
Using deep brain stimulation of the parietal cortex to investigate the electrophysiology of human episodic memoryR01NS107357 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI Bradley C Lega · 2018 to 2026
$3.6M
Behavioral and pharmacological manipulation of time cell activity in the human mesial temporal lobeR01NS125250 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI Bradley C Lega · 2022 to 2026
$1.8M
UT Southwestern Advancement of Neuroscience Research Careers (UTSWANS)UE5NS098987 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI ELAN D LOUIS, NADER POURATIAN · 2024 to 2026
$177k
NINDS NIH HHS R01 NS107357NINDS NIH HHS R01 NS125250NINDS NIH HHS RF1 NS126143NINDS NIH HHS UE5 NS098987
6 · The paper itself

Abstract

From an anatomical perspective, the concept that the anterior and posterior hippocampus fulfill distinct cognitive roles may seem unsurprising. When compared with the posterior hippocampus, the anterior region is proportionally larger, with visible expansion of the CA1 subfield and intimate continuity with adjacent medial temporal lobe (MTL) structures such as the uncus and amygdala. However, the functional relevance emerging from these anatomical differences remains to be established in humans. Drawing on both rodent and human data, several models of hippocampal longitudinal specialization have been proposed. For the brevity and clarity of this review, we focus on human electrophysiological evidence supporting and contravening these models with limited inclusion of noninvasive data. We then synthesize these data to propose a novel longitudinal model based on the amount of contextual information, drawing on previous conceptions described within the past decade.

Indexed as

Electrophysiological PhenomenaHippocampusModels, NeurologicalAnimalsHumanshippocampushuman electrophysiologylong-axis specialization

Identifiers

PMID39668062
PMCPMC12137022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.