ArticleBMJ mental health2024
Genetic variation in circadian regulator gene
Article in BMJ mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Social Rhythms, Depressive Symptoms, and Quality of Life: An Unbreakable Bond in an Older Adult Sample.International journal of environmental research and public health · 2026Observational
- Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its Diseases.Brain sciences · 2025Review
- Circadian rhythms and mental health.BMJ mental health · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe link between cardiometabolic disease and mental illness has been well established but remains incompletely explained. One hypothesis suggests that circadian rhythm dysregulation links cardiometabolic disease and mental illnesses.
objectiveWe investigated the
methodsGenetic and phenotypic data from UK Biobank (~500 000 participants) of White British, African-Caribbean, South Asian, white European and Multiple ancestries were used. Regression analyses using Plink 1.09 was used to identify significant associations, with Bonferroni multiple testing correction. Multiple ancestry meta-analyses using METAL software was used to investigate trans-ancestry consistency in genetic effects.
findingsWe identified associations for body mass index, anhedonia, diastolic and systolic blood pressure, waist-hip ratio, major depressive disorder, neuroticism and risk-taking. Meta-analyses indicated that there are ancestry-wide and ancestry-specific effects on cardiometabolic, mental illness and related traits.
conclusionsOur results suggest that the associations for mental illness (and related traits) and those for cardiometabolic traits are distinct rather than shared and that these associations were consistent across ancestry groups. CLINICAL IMPLICATIONS: Further investigation into the tissue-specific roles of
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Registered trials
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