Evidence map›Paper›PMID 39667847›Full record

ArticleAlcohol, clinical & experimental research2025

Maternal and paternal risk factors associated with diagnoses within the continuum of fetal alcohol spectrum disorders in the USA: Proximal and distal influences.

Philip A May, Julie M Hasken, Julie M Stegall, Heather A Mastro, Amy Baete, Jaymi Russo, Rosemary Bozeman, Mary Kay Burns, Jo-Viviane Jones, Wendy O Kalberg and 7 more

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Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Philip A MayNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.ORCID https://orcid.org/0000-0003-1939-8701
Julie M HaskenNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Julie M StegallNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Heather A MastroNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Amy BaeteSanford Health, Sioux Falls, SD, USA.
Jaymi RussoSanford Health, Sioux Falls, SD, USA.
Rosemary BozemanCity/County Health Department, USA.
Mary Kay BurnsCity/County Health Department, USA.
Jo-Viviane JonesCity/County Health Department, USA.
Wendy O KalbergCenter on Alcohol, Substance Use, and Addictions, University of New Mexico, Albuquerque, NM, USA.
David BuckleyCenter on Alcohol, Substance Use, and Addictions, University of New Mexico, Albuquerque, NM, USA.
Omar Abdul-RahmanSchool of Medicine, Department of Pediatrics, Cornell University, New York, NY, USA.
Margaret P AdamSchool of Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA.
Tamison JewettSchool of Medicine, Department of Pediatrics, Wake Forest University, Winston-Salem, NC, USA.
Luther K RobinsonSchool of Medicine, Department of Pediatrics, State University of New York at Buffalo, Buffalo, NY, USA.
Melanie A ManningDepartment of Pathology, School of Medicine, Stanford University, Palo Alto, CA, USA.
H Eugene HoymeSanford Health, Sioux Falls, SD, USA.

Funding

Prevalence and Traits of FASD in the US Population: Evidence from SchoolsU01AA019894 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAY, PHILIP ALAN · 2010 to 2017
$9.2M
NIAAA NIH HHS AA019894NIAAA NIH HHS U01 AA019894
6 · The paper itself

Abstract

backgroundWe sought to determine risk factors for fetal alcohol spectrum disorders (FASD) in the United States.

methodMothers of first-grade children participating in the Collaboration on FASD Prevalence (CoFASP) in three regional sites were interviewed. Maternal and paternal data were reported by mothers of children with an FASD diagnosis and controls.

resultsInterviews were conducted with mothers of children with an FASD (n = 114) and controls (n = 753). Fifty-seven percent of control mothers usually drank 2.7 drinks per drinking day (DDD) once per month prior to pregnancy, and 79% of mothers of children with FASD reported drinking 4.2 drinks 1-2 times per week. Mothers of children with alcohol-related neurodevelopmental disorder reported the most alcohol consumption overall: bingeing, drinking frequency, drinking in each trimester, and other drug use. Mothers of children with fetal alcohol syndrome (FAS) and partial FAS (PFAS) underreported consumption. Distal maternal risk factors were liver problems, depression, later pregnancy recognition and first prenatal visit, lower frequency of marriage, and lower spirituality. Postnatal risk indicators were low birthweight and gestational age. Regression analysis indicated that maternal reports of three DDD before pregnancy were associated with a diagnosis within the FASD continuum (p < 0.001, OR = 9.92). First-trimester exposure (p < 0.001, OR = 7.64) and all three trimesters (p < 0.001, OR = 7.77) were associated with a child's FASD diagnosis. An independent association was found between paternal DDD during pregnancy and FASD diagnoses (p = 0.002, OR = 1.08); but, once maternal drinking was a covariate, paternal influence was not significant. Stepwise models indicated that combined maternal alcohol use measures (p < 0.001, χ

conclusionWhile multiple, significant maternal risk factors for FASD were identified, paternal drinking was not a statistically significant, independent risk factor.

Indexed as

fetal alcohol Spectrum disordersmaternal riskUnited States

Identifiers

PMID39667847
PMCPMC11747830

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