Evidence map›Paper›PMID 39667814›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Antibody-Based PET Imaging of Misfolded Superoxide Dismutase 1 in an Amyotrophic Lateral Sclerosis Mouse Model.

Jacques A Rousseau, Marcel Maier, Samia Ait-Mohand, Véronique Dumulon-Perreault, Otman Sarrhini, Sébastien Tremblay, Etienne Rousseau, Michael Salzmann, Brigitte Guérin

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A phase I study to evaluate the dosimetry and safety of [European journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacques A RousseauDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Marcel MaierAL-S Pharma AG, Schlieren, Zurich, Switzerland; and.
Samia Ait-MohandDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Véronique Dumulon-PerreaultSherbrooke Molecular Imaging Center/Centre de Recherche du CHUS, Sherbrooke, Québec, Canada.
Otman SarrhiniDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Sébastien TremblayDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Etienne RousseauDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Michael SalzmannAL-S Pharma AG, Schlieren, Zurich, Switzerland; and.
Brigitte GuérinDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada; brigitte.guerin2@usherbrooke.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease characterized by motor neuron loss in the motor cortex, brain stem, and spinal cord. Mutations in the superoxide dismutase 1 (SOD1) gene, resulting in misfolding of its protein product, are a common cause of ALS. Currently, there is no approved ALS diagnostic tool. Here, we present the development of a PET radiotracer, [

Indexed as

Amyotrophic Lateral SclerosisDisease Models, AnimalPositron-Emission TomographySuperoxide Dismutase-1ZirconiumAnimalsAntibodiesDeferoxamineMiceMice, TransgenicProtein FoldingRadioisotopesTissue DistributionAntibodiesDeferoxamineRadioisotopesSuperoxide Dismutase-1ZirconiumZirconium-89[89Zr]Zr-DFO-α-miSOD1ALS transgenic miceamyotrophic lateral sclerosismisfolded superoxide dismutase 1PET imaging

Identifiers

PMID39667814
PMCPMC11705793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.