Evidence map›Paper›PMID 39667721›Full record

ArticleBritish journal of haematology2025

Acalabrutinib in combination with rituximab and lenalidomide in patients with relapsed or refractory follicular lymphoma: Results of the phase 1b open-label study (ACE-LY-003).

Paolo Strati, Richy Agajanian, Izidore S Lossos, Morton Coleman, Robert Kridel, Andrew Wood, Robin Lesley, Chuan-Chuan Wun, Deborah M Stephens

Abstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Review
  4. Review
  5. Towards a chemo-free approach for follicular lymphoma.British journal of haematology · 2025
    Review
  6. A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paolo StratiThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-7445-1459
Richy AgajanianThe Oncology Institute of Hope and Innovation, Downey, California, USA.
Izidore S LossosSylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, Florida, USA.ORCID https://orcid.org/0000-0002-9346-9013
Morton ColemanClinical Research Alliance/Weill Cornell Medicine, New York, New York, USA.
Robert KridelPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-0287-7124
Andrew WoodAstraZeneca, Cambridge, UK.
Robin LesleyAstraZeneca, South San Francisco, California, USA.
Chuan-Chuan WunAstraZeneca, South San Francisco, California, USA.
Deborah M StephensUniversity of North Carolina Lineberger Cancer Center, Chapel Hill, North Carolina, USA.

Funding

AstraZeneca
6 · The paper itself

Abstract

Patients with relapsed/refractory (R/R) follicular lymphoma (FL) have limited effective treatment options. Bruton tyrosine kinase inhibitors (BTKis) increase the anti-tumoural phenotype of tumour-associated macrophages, providing rationale to combine them with rituximab and lenalidomide (R

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBenzamidesLymphoma, FollicularPyrazinesAdultAgedAged, 80 and overCOVID-19FemaleHumansLenalidomideMaleMiddle AgedRituximabacalabrutinibBenzamidesLenalidomidePyrazinesRituximabB‐cell lymphomaBruton tyrosine kinase inhibitorimmunotherapynon‐Hodgkin lymphoma

Identifiers

PMID39667721
PMCPMC11886943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.