ArticleEarly human development2025
Placental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy.
Article in Early human development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Association of fetal inflammatory response with brain MRI findings and neurodevelopmental outcomes in preterm infants.Pediatric research · 2026Article
- A collaborative "THRIVE Fetus to Five" neonatal brain program review.Pediatric research · 2026Review
- Emerging modalities for neuroprognostication in neonatal encephalopathy: harnessing the potential of artificial intelligence.Pediatric research · 2025Review
- Multi-organ dysfunction across the neonatal encephalopathy spectrum.Pediatric research · 2025Article
- Multi-organ involvement in preterm neonatal encephalopathy.Early human development · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPlacental lesions are associated with worse neonatal outcomes, but their association with neonatal hypoxic-ischemic encephalopathy (HIE), including the full range of severity from mild to severe HIE, has not been well described.
objectiveTo determine the association of acute and chronic placental lesions with mild versus moderate to severe HIE; secondarily, to assess the impact of multiple placental lesions on severity of HIE.
methodsThis retrospective study of prospectively collected data included neonates born at ≥36 weeks, with a birth weight of >1800 g, diagnosed with HIE between January 2012 and November 2022. The cohort was divided into those with mild versus moderate to severe HIE, based on the modified Sarnat staging. Placental histologic diagnoses were made according to the Amsterdam Placental Workshop Group Consensus Statement. Placental pathologic lesions were classified into acute inflammation with attention to stages and grades of maternal and fetal inflammatory responses (MIR and FIR, respectively), maternal vascular malperfusion, fetal vascular malperfusion, villitis of unknown etiology, and other lesions. Chi-square and Fisher's exact test were used to compare rates of placental pathologies between mild and moderate to severe HIE groups.
resultsOf 394 neonates ≥36 weeks' gestation diagnosed with HIE, 172 had mild HIE and received supportive care, while 180 had moderate to severe HIE and underwent therapeutic hypothermia. 42 patients were excluded due to lack of placental pathology reports. FIR was significantly associated with moderate to severe HIE vs. mild HIE (53 % vs. 38 %, P < 0.01). Higher grade and stage of FIR was also associated with worse severity of HIE (moderate to severe HIE showed FIR stage ≥2 in 81 % and grade 2 in 15 % vs. 34 % and 3 % in those with mild HIE, respectively). MIR was diagnosed in more placentas from the moderate to severe HIE group (58 % vs. 47 %, P = 0.04) with higher stage and grade MIR in patients with moderate to severe HIE (86 % with MIR stage ≥2 and 19 % with MIR grade 2). High-grade (patchy/diffuse) chronic villitis was more prevalent in the moderate to severe HIE group vs. mild HIE group (18 % vs. 8 %, P < 0.01).
conclusionThere is a higher prevalence of placental inflammatory lesions in neonates with moderate to severe HIE compared to those with mild HIE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.