Evidence map›Paper›PMID 39667018›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex.

Oliver Baretella, Manuel R Blum, Nazanin Abolhassani, Heba Alwan, Lea Wildisen, Cinzia Del Giovane, Kali Tal, Elisavet Moutzouri, Bjørn O Åsvold, Anne R Cappola and 22 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Oliver BaretellaInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-1103-1921
Manuel R BlumInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-4638-775X
Nazanin AbolhassaniInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-3616-3595
Heba AlwanInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-5516-6022
Lea WildisenInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-2097-8674
Cinzia Del GiovaneInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-5028-932X
Kali TalInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-2454-2560
Elisavet MoutzouriInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-7713-7553
Bjørn O ÅsvoldHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0003-3837-2101
Anne R CappolaDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-5160, USA.ORCID 0000-0002-0883-9754
Jacobijn GusseklooLUMC Center for Medicine for older people, Department of Public Health and Primary Care, and Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZD Leiden, the Netherlands.ORCID 0000-0001-7186-8278
Massimo IacovielloCardiology Unit, Emergency and Organ Transplantation Department, University of Bari, 70124 Bari, Italy.ORCID 0000-0001-9613-5062
Giorgio IervasiNational Research Council, Institute of Clinical Physiology, Tuscany Region G. Monasterio Foundation, 56124 Pisa, Italy.ORCID 0000-0001-6805-541X
Misa ImaizumiDepartment of Clinical Studies, Radiation Effects Research Foundation, Nagasaki 850-0013, Japan.
Stefan WeilerDepartment of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH, 8093 Zurich, Switzerland.ORCID 0000-0003-1087-7597
Salman RazviTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.ORCID 0000-0002-9047-1556
José A SgarbiDivision of Endocrinology, Faculdade de Medicina de Marília, Marília, São Paulo 17519, Brazil.ORCID 0000-0001-7187-984X
Henry VölzkeInstitute for Community Medicine, SHIP/Clinical-Epidemiological Research, University Medicine Greifswald, 17489 Greifswald, Germany.ORCID 0000-0001-7003-399X
Suzanne J BrownMedical School, University of Western Australia, Crawley, Western Australia 6009, Australia.ORCID 0000-0002-8413-561X
John P WalshMedical School, University of Western Australia, Crawley, Western Australia 6009, Australia.ORCID 0000-0002-1766-2612
Bert VaesDepartment of Public Health and Primary Care, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-5244-1930
Bu B YeapMedical School, University of Western Australia, Perth, Western Australia 6009, Australia.ORCID 0000-0002-7612-5892
Robin P F DullaartDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.ORCID 0000-0003-4520-1239
Stephan J L BakkerDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.ORCID 0000-0003-3356-6791
Maryam KavousiDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, the Netherlands.ORCID 0000-0001-5976-6519
Graziano CeresiniUnit of Internal Medicine and Oncological Endocrinology, University of Parma, University Hospital Parma, 43121 Parma, Italy.ORCID 0000-0003-3347-4096
Luigi FerrucciNational Institutes on Aging, Longitudinal Studies Section, Baltimore, MD 21225-1233, USA.ORCID 0000-0002-6273-1613
Drahomir AujeskyDepartment of General Internal Medicine, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.ORCID 0000-0002-3970-2670
Robin P PeetersDepartment of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, the Netherlands.ORCID 0000-0001-7732-9371
Douglas C BauerInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-5261-7721
Martin FellerInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-2519-836X
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-9083-6896

Funding

Midcareer Investigator Award in Patient-Oriented Research in AgingK24AG042765 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2013 to 2024
$1.7M
NIA NIH HHS K24 AG042765Swiss National Science Foundation 32003B_200606University of Bern
6 · The paper itself

Abstract

contextSubclinical thyroid dysfunction (ScTD), comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper), has been associated with increased risk for cardiovascular events.

objectiveTo assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex.

methodsThis analysis of pooled participant data from large prospective cohort studies from the Thyroid Studies Collaboration assessed cvRFs (blood pressure [BP], lipid levels, high-sensitivity C-reactive protein [hs-CRP]) among participants aged 18 to 103 years with SHypo (thyroid-stimulating hormone [TSH] > 4.50 mU/L, normal fT4) and SHyper (TSH < 0.45 mU/L, normal fT4) vs euthyroid (TSH 0.45-4.50 mU/L).

resultsOf 69 006 participants (mean age 62 years, 55% women, 25% current smokers) from 16 international cohorts, 3748 (5.4%) had SHypo and 3428 (5.0%) had SHyper. In both women and men, systolic and diastolic BP were similar regardless of thyroid status. Exceptions were lower diastolic BP in women with SHyper compared to euthyroid participants (adjusted mean difference [aMD] -1.3 mmHg, 95% CI -2.0 to -0.5), and lower systolic BP in men with SHyper compared to euthyroid participants (aMD -3.1 mmHg, 95% CI -4.8 to -1.4). In both women and men, lipid levels (total, HDL, LDL-cholesterol, triglycerides) and hs-CRP were similar regardless of thyroid status. The only exception were women with SHyper who had lower LDL-cholesterol vs euthyroid (aMD -0.17 mmol/L, 95% CI -0.29 to -0.05).

conclusionParticipants with ScTD and euthyroid participants have similar cvRFs and differences are arguably too small to explain the increased cardiovascular risk in ScTD observed in previous studies.

Indexed as

Cardiovascular DiseasesHeart Disease Risk FactorsHyperthyroidismHypothyroidismThyroid DiseasesAdolescentAdultAgedAged, 80 and overAge FactorsBlood PressureFemaleHumansMaleMiddle AgedProspective StudiesThyrotropinarterial hypertensiondyslipidemiahigh-sensitivity C-reactive proteinLDL-cholesterolsubclinical hyperthyroidismsubclinical hypothyroidism

Identifiers

PMID39667018
PMCPMC12012810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.