ArticlePloS one2024
Preparation and cell imaging of a nido-carborane fluorescent complex based on multi-component polymerization.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
The biocompatibility of carborane was a difficult problem that had drawn a lot of study interest. Using multi-ion inlay binding, water-soluble polymers were created by encapsulating nido-carborane in diazaspirodecaniums such as para-poly-nido-carboanylazaspirodecanium [5,4] (p-PNC54), para-poly-nido-carboanylazaspirodecanium [6,5] (p-PNC65), meta-poly-nido-carboanylazaspirodecanium [5,4] (m-PNC54), and meta-poly-nido-carboanylazaspirodecanium [6,5] (m-PNC65). First, the active control 5-fluorouracil demonstrated strong activity against HeLa and HCT-116 cells but minimal cytotoxicity at 19.22±2.85 μM and 21.47±5.99 μM, respectively. Second, the four carborane polymers that specifically penetrated the cells were imaged using HeLa cells. TEM was used to assess the dynamic self-assembling effect of these water-soluble polymers in order to gain a better understanding of their internal microphenomenon. All four derivatives' combined impacts on self-assembly in water were identified. Different degrees of selective entrance into targeted cells under different architectures were discovered by in vitro cell imaging.
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