ArticleJournal of food and drug analysis2022
Stress amelioration and anti-inflammatory potential of Shiikuwasha (Citrus depressa Hayata) essential oil, limonene, and γ-terpinene.
Article in Journal of food and drug analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Smelling Wellness: Associations Between Botanic Garden Scentscapes and Human Health Gains.International journal of environmental research and public health · 2026Trial
- Relaxation effects of Shikuwasa (Contemporary clinical trials communications · 2026Article
- Flavor and Well-Being: A Comprehensive Review of Food Choices, Nutrition, and Health Interactions.Food science & nutrition · 2025Review
- Investigation of the differences in volatile organic compounds of sesame oil under different processing methods using GC-IMS and electronic nose.Frontiers in nutrition · 2025Article
- Evaluating the relaxation effects of Shikuwasa (Citrus depressa Hayata) essential oil inhalation in young female adults: Study protocol for a randomised controlled trial.Contemporary clinical trials communications · 2024Article
- Investigating the Potential of Essential Oils fromPlants (Basel, Switzerland) · 2024Article
- Novel Electromagnetic Heat Hydrodistillation for Extraction of Essential Oil from Tangerine Peel.Foods (Basel, Switzerland) · 2024Article
- Article
- Multivariate Profiling of Metabolites and Volatile Organic Compounds inFoods (Basel, Switzerland) · 2023Article
- Citrus By-Products as a Valuable Source of Biologically Active Compounds with Promising Pharmaceutical, Biological and Biomedical Potential.Pharmaceuticals (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shiikuwasha (Citrus depressa Hayata) essential oil (SEO) extracted from Shiikuwasha fruit pulp contains two major volatile components, limonene and γ-terpinene (56.56-57.31 and 24.41-24.98%, respectively). In this study, we showed that the aroma streams of SEO, limonene, and γ-terpinene exhibited significant physiological stress amelioration effects in nine healthy female panelists tested in a 30-min visual display task. While SEO administration significantly reduced work errors by 15 min compared to the odorless control condition, the limonene stream reduced work errors only at the first and fourth 5-min intervals, and the γ-terpinene effect lasted only for the initial 5-min. However, γ-terpinene inhalation reduced stress by significantly increasing post-work electrocardiogram R-R interval variability and lowering electroencephalogram beta wave powers at the midline occipital Oz position. Additionally, SEO, limonene, and γ-terpinene displayed anti-inflammatory activity in vitro by suppressing the pro-inflammatory markers NO and IL-1β in BV-2 microglial cells in a dose-dependent manner.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.