Evidence map›Paper›PMID 39666267›Full record

ArticleClinical journal of gastroenterology2025

The efficacy of JAK inhibitors in adult eosinophilic colitis with atopic dermatitis; four cases report.

Hiroshi Matsumto, Momoyo Sasahira, Yasuhito Fujimoto, Shogen Yo, Akiko Shiotani

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hiroshi MatsumtoDepartment of Internal Medicine, Division of Gastroenterology, Kawasaki Medical School, Kurashiki City, Japan. hmatsumoto0311@gmail.com.ORCID http://orcid.org/0000-0003-2810-2888
Momoyo SasahiraDepartment of Internal Medicine, Division of Gastroenterology, Kawasaki Medical School, Kurashiki City, Japan.
Yasuhito FujimotoDepartment of Pathology, Kawasaki Medical School, Kurashiki City, Japan.
Shogen YoDepartment of Internal Medicine, Division of Gastroenterology, Kawasaki Medical School, Kurashiki City, Japan.
Akiko ShiotaniDepartment of Internal Medicine, Division of Gastroenterology, Kawasaki Medical School, Kurashiki City, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein present four cases of Eosinophilic colitis (EoC) in adult patients who were successfully treated with a Janus kinase (JAK) inhibitor. Case 1 is a 23-year-old female who was treated with baricitinib (BAR, 4 mg, once a day) for atopic dermatitis (AD). Colonoscopy (CS) initially did not reveal any significant abnormalities. However, she underwent another CS when she underwent a food challenge test involving wheat without baricitinib medication. During this procedure, the CS subsequently leading to her diagnosis of EoC based on eosinophil infiltration. Case 2 is a 26-year-old man whereas Case 3 is a 40-year-old man. Both patients were started on upadacitinib (UPA, 15 mg, once daily) for the treatment of AD. Their abdominal symptoms improved, and colonic histology revealed the disappearance of eosinophils. Case 4, on the other hand, is a 29-year-old woman who was also started on UPA (15 mg, once daily). Her skin lesions and abdominal symptoms also improved within 2 weeks. To the best of our knowledge, this is the first novel clinical observational case report on the efficacy of JAK inhibitors in treating adult patients with both EoC and AD.

Indexed as

ColitisDermatitis, AtopicEosinophiliaJanus Kinase InhibitorsAdultAzetidinesColonoscopyFemaleHeterocyclic Compounds, 3-RingHumansMalePurinesPyrazolesSulfonamidesYoung AdultAzetidinesHeterocyclic Compounds, 3-RingJanus Kinase InhibitorsPurinesPyrazolesSulfonamidesupadacitinibAtopic dermatitisEosinophilic colitisEosinophilic Gastrointestinal Disease (EGID)Gut-skin axisJAK inhibitor

Identifiers

PMID39666267

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.