Evidence map›Paper›PMID 39666263›Full record

ReviewJournal of neuro-oncology2025

Primary diffuse leptomeningeal glioblastoma: a case report and literature review.

Mark Willy L Mondia, Rebekka E Hooks, Georgios A Maragkos, Vanessa L Smith, Matthew R McCord, Joseph H Donahue, Eli S Williams, M Beatriz Lopes, David Schiff, Ashok R Asthagiri

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mark Willy L MondiaDivision of Neuro-Oncology, Department of Neurology, University of Virginia, 1300, Jefferson Park Avenue West Complex Room 6225, Charlottesville, 22908, VA, USA. wpz3tm@uvahealth.org.ORCID http://orcid.org/0000-0001-8862-5360
Rebekka E HooksDivision of Neuro-Oncology, Department of Neurology, University of Virginia, 1300, Jefferson Park Avenue West Complex Room 6225, Charlottesville, 22908, VA, USA.
Georgios A MaragkosDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Vanessa L SmithDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
Matthew R McCordDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
Joseph H DonahueDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Eli S WilliamsDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
M Beatriz LopesDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
David SchiffDivision of Neuro-Oncology, Department of Neurology, University of Virginia, 1300, Jefferson Park Avenue West Complex Room 6225, Charlottesville, 22908, VA, USA.
Ashok R AsthagiriDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGlioblastoma (GBM) that presents as leptomeningeal disease (LMD) is extremely rare and fatal. Limited data are available regarding incidence, clinical presentation, and management. Prognosis is poor and no treatment is known to improve survival. METHODS AND

resultsWe present a case report of a 72-year-old female who presented with depressed sensorium, ataxia, and myelopathy. Magnetic resonance imaging (MRI) showed diffuse supratentorial and spinal LMD. There was an absence of any detectable and distinct intraparenchymal lesion on neuroaxis imaging. Biopsy of the Sylvian fissure nodule revealed GBM. Steroid therapy was ineffective for symptom relief. She opted for palliative care and expired shortly after diagnosis.

conclusionTo our knowledge, this is the first reported case of GBM presenting exclusively as LMD without a primary lesion. If systemic imaging techniques do not provide a biopsy target and cerebrospinal fluid (CSF) studies are non-diagnostic, tissue diagnosis from leptomeningeal biopsy is recommended. Palliative chemoradiation or best supportive care are reasonable treatment options.

Indexed as

GlioblastomaMeningeal NeoplasmsAgedFatal OutcomeFemaleHumansMagnetic Resonance ImagingGBMGlioblastomaLeptomeningeal diseaseLeptomeningeal spreadLMDLMS

Identifiers

PMID39666263
PMCPMC11832630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.