ArticleJournal of neurology2024
Different patterns of acute saccadic response to levodopa in de novo Parkinson's disease.
Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The spectrum of square wave jerks in essential tremor: an exploratory study.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundL-dopa (LD) effects on visually guided saccades (VGS) have been poorly investigated in de novo Parkinson's disease (PD) patients through a standardized acute challenge test.
objectivesTo assess the acute saccadic effects of LD as well as possible different patterns of VGS response to LD in a consistent population of de novo PD.
methodsVGS were assessed among de novo PD at baseline and 2 h after the administration of LD/carbidopa 250/25 mg. Baseline instrumental assessments were compared with healthy controls (HCs).
resultsThirty-two de novo PD and 17 HCs were enrolled. PD patients showed lower upward velocities and amplitude than HCs, improving after LD administration. Two subgroups were identified among PD patients based on percent improvement or worsening of the most significant changing VGS parameter after LD administration: Group A (19 patients, showing improvement) and B (13 patients, showing worsening). Group A had at baseline reduced vertical, especially downward, velocities, gain and amplitude compared to Group B, with a significant improvement after LD. Conversely, in Group B, an LD-induced worsening effect on both horizontal and vertical VGS parameters was found. Comparing the two identified groups based on clinical-demographic characteristics, higher prevalence of female sex was found in Group B.
conclusionsDe novo PD patients presented prominent vertical VGS impairment which improved acutely after LD administration. Different patterns of acute saccadic responses to LD were also shown, suggesting a possible role of VGS in PD phenotyping.
Indexed as
Identifiers
39666178What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.