Evidence map›Paper›PMID 39666126›Full record

ArticleArchives of dermatological research2024

Investigation of clinical and subclinical renal damage in Psoriasis.

Belgin Kucukyangoz, Mualla Polat, Mustafa Kucukyangoz, Guler Bugdayci, Ahmet Metin

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Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Belgin KucukyangozDepartment of Dermatology, Necip Fazil City Hospital, Kahramanmaras, Turkey.
Mualla PolatDepartment of Dermatology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Mustafa KucukyangozDepartment of Urology, Necip Fazil City Hospital, Kahramanmaras, Turkey. kucukyangoz42@hotmail.com.ORCID http://orcid.org/0000-0003-4766-7454
Guler BugdayciDepartment of Biochemisty, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Ahmet MetinDepartment of Urology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a common systemic inflammatory disease and the literature has reported varying results regarding the renal involvement of psoriasis. Although many studies have investigated the presence of chronic renal damage in patients with psoriasis, there are few studies demonstrating subclinical renal damage. The aim of this study was to prospectively evaluate the presence of clinical and subclinical renal damage in patients with psoriasis vulgaris (PV). The study prospectively enrolled 44 PV patients and 44 healthy controls. Serum urea (BUN), creatinine levels, glomerular filtration rate (GFR), complete urinalysis, urine microscopy and subclinical renal damage markers albuminuria, proteinuria, urinary kidney injury molecule-1 (uKIM-1)/creatinine, urinary neutrophil gelatinase-associated lipocalin (uNGAL)/creatinine and urinary podocalyxin/creatinine levels were measured and compared in both groups.Proteinuria levels were found to be statistically significantly higher in patients with PV (p = 0.021). A positive correlation was observed between proteinuria levels and uKIM-1/creatinine, uNGAL/creatinine and albuminuria levels in the patient group (p = 0.013, r = 0.373; p = 0.017, r = 0.358; p = 0.017, r = 0.358, respectively). This study concluded that PV does not cause clinical kidney injury. Increased proteinuria in PV patients supports the presence of subclinical renal damage. Regular monitoring of proteinuria and uKIM-1/creatinine, uNGAL/creatinine and albuminuria levels, which are positively correlated with proteinuria, may allow early detection of renal damage in PV patients.

Indexed as

BiomarkersPsoriasisAdultAlbuminuriaCase-Control StudiesCreatinineFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidneyLipocalin-2MaleMiddle AgedProspective StudiesProteinuriaBiomarkersCreatinineHepatitis A Virus Cellular Receptor 1Lipocalin-2KIM-1NGALPodocalyxinPsoriasisRenal damage

Identifiers

PMID39666126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.