Synthesis of platinum nanoparticles functionalized with glutamine and conjugated with thiosemicarbazone and their cytotoxic effects on MDA-MB-231 breast cancer cell line and evaluation of CASP-8 gene expression.

Nabeel Rahi Mashkoor, Salwan Ali Abed, Arash Davoudi, Zahraa Aqeel Adel Jassim, Zainab Yousif Faraj, Fatemeh Akbari, Fahimeh Abedini Bajgiran, Mohammad Hedayati, Ali Salehzadeh

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Nabeel Rahi MashkoorDepartment of Pathological Analysis, College of Science, AL-Qadisiyah University, Al Diwaniyah, AL-Qadisiyah, Iraq.

Salwan Ali AbedEnvironmental Science Department, College of Science, AL-Qadisiyah University, Al Diwaniyah, AL-Qadisiyah, Iraq.

Arash DavoudiDivision of Cytogenetic, Dr. Keshavarz Medical Genetics Lab, Rasht, Iran.

Zahraa Aqeel Adel JassimScientific Affairs Department, AL-Qadisiyah University, Al Diwaniyah, AL-Qadisiyah, Iraq.

Zainab Yousif FarajScientific Affairs Department, AL-Qadisiyah University, Al Diwaniyah, AL-Qadisiyah, Iraq.

Fatemeh AkbariDepartment of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

Fahimeh Abedini BajgiranDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.

Mohammad HedayatiGuilan University of Medical Sciences, Rasht, Iran.

Ali SalehzadehDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran. a.salehzadeh@iau.ac.ir.

Funding

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6 · The paper itself

Abstract

Breast cancer (BC) is the most prevalent form of cancer among women and is a major contributor to cancer-related fatalities. Nanotechnology has provided novel approaches to drug delivery to cancer cells. In this work, we synthesized platinum (Pt) nanoparticles, functionalized them with glutamine, conjugated them with thiosemicarbazone (TSC), and characterized their anticancer effects on the MDA-MB-231 breast cancer cell line. Characteristics of the nanoparticles were assessed by FT-IR, XRD, EDS mapping, SEM, TEM, DLS, and zeta potential measurement. Cell viability was characterized by MTT assay, and cell necrosis/apoptosis levels were determined by flow cytometry. The expression level of the CASP-8 gene was investigated by real-time PCR. Pt@Gln-TSC nanoparticles are spherical, 20-70 nm in diameter in dry form, 662 nm after hydration, and their zeta potential was - 6.6 mV. The 50% inhibitory concentration (IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsCaspase 8GlutamineMetal NanoparticlesPlatinumThiosemicarbazonesApoptosisCell Line, TumorCell SurvivalFemaleGene Expression Regulation, NeoplasticHumansAntineoplastic AgentsCASP8 protein, humanCaspase 8GlutaminePlatinumThiosemicarbazonesApoptosisBreast cancerFlow cytometryPlatinum nanoparticlesThiosemicarbazone

Identifiers

PMID39665983

DOI10.1007/s00210-024-03629-z

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