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ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Rhazes' insights on abortion and abortogenic drugs in relation to modern concepts.

Mohammad Amrollahi-Sharifabadi, Jamal Rezaei Orimi, Syed Mohd Abbas Zaidi, Toheeb Olalekan Oladejo, Abdur Rahman, Sageer Abass, Sayeed Ahmad, Sahar Abdelaziz, Mohammad Bahrami-Tapehbour, Marwa M M Fawzy and 1 more

Abstract readHistorical Article
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammad Amrollahi-SharifabadiDepartment of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, 5th Kilometer of Khorramabad-Boroujerd Highway, Khorramabad, 68151-44316, Iran. amrollahi.m@lu.ac.ir.ORCID 0000-0002-4458-7689
Jamal Rezaei OrimiPre-hospital Emergency Medical Services and Disaster Management Center, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0002-2356-5552
Syed Mohd Abbas ZaidiDepartment of Moalajat (Internal Medicine), Hakim Syed Ziaul Hasan (HSZH) Government Unani Medical College, Bhopal, 462003, India.ORCID 0000-0002-7599-4041
Toheeb Olalekan OladejoDepartment of Pharmacology and Toxicology, Nazarbayev School of Medicine, Astana, Kazakhstan.ORCID 0000-0003-2970-3394
Abdur RahmanCentre of Excellence in Unani Medicine (Pharmacognosy and Pharmacology), Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Sageer AbassCentre of Excellence in Unani Medicine (Pharmacognosy and Pharmacology), Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.ORCID 0000-0001-5288-2752
Sayeed AhmadCentre of Excellence in Unani Medicine (Pharmacognosy and Pharmacology), Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. sahmad_jh@yahoo.co.in.ORCID 0000-0003-1573-152X
Sahar AbdelazizDepartment of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.ORCID 0000-0001-9475-6121
Mohammad Bahrami-TapehbourDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, 68151-44316, Iran.ORCID 0009-0001-8242-5701
Marwa M M FawzyDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha, Egypt.ORCID 0000-0002-4437-7681
Morteza MojahediTraditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. mortazamojahedy@gmail.com.ORCID 0000-0002-0346-5925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abortion remains one of the most prevalent complications of pregnancy, contributing significantly to maternal mortality and presenting a substantial public health challenge. This study aimed to explore Rhazes' perspective on abortion and abortifacient medicinal plants he mentioned in Kitāb al-Ḥāwī fī al-Ṭibb. A detailed analysis of his seminal work, Kitāb al-Ḥāwī fī al-Ṭibb, was conducted. Relevant keywords such as abortion, stillbirth, fetus, drugs, and abortifacients were examined within Kitāb al-Ḥāwī fī al-Ṭibb. The analysis included Rhazes' viewpoints on abortion and the abortogenic drugs he mentioned, as well as their methods of administration, including oral dosage forms and vaginal formulations. Furthermore, relevant current literature was used to find the potential scientific rationales for Rhazes' insights. Our findings indicate that Rhazes contributed to obstetrics and gynecology as he discussed abortion, its prevention, and management in his book. Also, he identified various medicinal plants with potential abortogenic properties. Rhazes explained various administration methods, including rub, decoction, inhalation, suppository, enema, incense, and water bath. Even though his clinical practices and detailed observations provide a rich context for understanding the historical use of these agents, evidence-based medical practices need to be conducted to cleave potentially usable parts of Rhazes' perspectives and his approaches to the prevention and treatment of abortion. Moreover, there is a pressing need for well-designed randomized clinical trials to rigorously evaluate the potential efficacy and safety of the medical insights and the potential therapeutic herbal agents he described.

Indexed as

Abortifacient AgentsAbortion, InducedPlants, MedicinalFemaleHumansPhytotherapyPregnancyAbortifacient AgentsAbortionPersian medicinePharmacologyRhazesToxicologyUnani medicine

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.