ArticleProceedings of the National Academy of Sciences of the United States of America2024
Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Who cites it
7 citing papers in PubMed.
- Male reproductive biology was reshaped during placental mammal diversification through epididymal secretome expansion.EMBO reports · 2026Article
- Immunological dynamics of the epididymis: from experimental insights to clinical translation.Reproduction & fertility · 2026Review
- Genome Editing for Fertility: Unlocking the Promise of CRISPR/Cas9 in Addressing Male Infertility - A Narrative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Ovochymase 2 is a key regulatory factor modulating proteolytic pathways and sperm maturation in the mammalian epididymis†.Biology of reproduction · 2025Article
- WFDC3 identified as a prognostic and immune biomarker in pancreatic cancer.Biomolecules & biomedicine · 2025Article
- Understanding the roles of the WFDC cluster in sperm development and function.Nature reviews. Urology · 2025Article
- Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Katarzyna KentCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-4528-3425
Kaori NozawaCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Rachel ParkesCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Laura DeanCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Frey DanielCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
Mei LengMass Spectrometry Proteomics Core, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.
Antrix JainMass Spectrometry Proteomics Core, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-2815-3645
Anna MalovannayaMass Spectrometry Proteomics Core, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-2953-6485
Martin M MatzukCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0002-1445-8632
Thomas X GarciaCenter for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-7761-2660
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MGenetics & Genomics Training ProgramT32GM139534 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI GAD SHAULSKY · 2021 to 2026
$4.8MFunctional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5MSearch for new genes involved in male infertility through novel approachesR01HD106056 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Thomas Garcia · 2022 to 2026
$2.7MComprehensive Mechanisms in Reproductive SciencesT32HD098068 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI STEPHANIE A. PANGAS · 2020 to 2026
$2.4MFUNCTIONAL GENOMICS AND PROTEOMICS TO REVEAL REPRODUCTIVE-TRACT SPECIFIC PROTEINSR01HD095341 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, THOMAS · 2018 to 2020
$1.2MTHERMO SCIENTIFIC Q EXACTIVE HF-X HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETERS10OD026804 · OD · BAYLOR COLLEGE OF MEDICINE · PI MALOVANNAYA, ANNA · 2019 to 2019
$717kMyD88-dependent mechanisms of Helicobacter pylori-induced gastric cancer progressionR21CA210227 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OBONYO, MARYGORRET · 2017 to 2018
$371kA.I. & Manet Schepps Discovery Foundation FellowshipCancer Prevention and Research Institute of Texas (CPRIT) RP170005Cancer Prevention and Research Institute of Texas (CPRIT) RP210227HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P50HD103555HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD088412HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD095341HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD106056HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) T32HD098068HHS | NIH | National Cancer Institute (NCI) P30CA125123HHS | NIH | NIH Office of the Director (OD) S10OD026804Japan Society for the Promotion of Science Overseas Research FellowshipLalor Foundation (The Lalor Foundation) FellowshipMale Contraceptive Initiative 2021-302NCI NIH HHS P30 CA125123NICHD NIH HHS P50 HD103555NICHD NIH HHS R01 HD088412NICHD NIH HHS R01 HD095341NICHD NIH HHS R01 HD106056NICHD NIH HHS T32 HD098068NIGMS NIH HHS T32 GM139534NIH HHS S10 OD026804
Abstract
Despite 96 million years of evolution separating humans and rodents, 11 closely related reproductive tract-specific genes in humans-
Indexed as
CRISPR-Cas SystemsInfertility, MaleMultigene FamilyAnimalsFemaleFertilityGene DeletionHumansMaleMiceMice, KnockoutProteinase Inhibitory Proteins, SecretoryReproductionSpermatogenesisSpermatozoaSperm MotilityProteinase Inhibitory Proteins, SecretoryCRISPR/Cas9infertilityKunitz domainspermiogenesisWAP domain
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.