ArticleProceedings of the National Academy of Sciences of the United States of America2024
Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Oral Actinobacteria sense and defend against parasitic epibionts.bioRxiv : the preprint server for biology · 2026Article
- Genome-based predictions of metabolic preferences and substrate phenotypes in psychrotrophic bacteria from permafrost environments.Microbiology spectrum · 2026Article
- Tracking interlinked microbial and geochemical succession over decades in landfilled municipal solid waste.Applied and environmental microbiology · 2026Article
- Microbial consortia mediating lignocellulose turnover and denitrification in eutrophic lake sediment enrichments.mSystems · 2026Article
- Environmental variation structures northern peatland soil microbiome composition and function in a reindeer herding area exclosure experiment.FEMS microbiology ecology · 2026Article
- Endophytic microbiota and metabolites profile in gynoecious versus monoecious cucumbers.BMC plant biology · 2026Article
- Arctic deep-sea hydrothermal microbiomes as a natural niche for novel antimicrobial peptides.BMC microbiology · 2026Article
- Oxycodone self-administration and genetic background exert community-specific effects in the gut microbiome.Scientific reports · 2026Article
- Ultrasmall oral Saccharibacteria modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis.Nature communications · 2026Article
- Household environmental characteristics influence the house dust metagenome.Environmental research · 2026Article
- Sulfur Oxidation by New and Non-Canonical Bacteria in a Subsurface Flow Constructed Wetland Treating Domestic Wastewater.Microorganisms · 2026Article
- Linking topography, soil physicochemical traits and bacterial community dynamics in a managed tea landscape.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Metagenomics reveals potential interactions between Patescibacteriota and their phages in groundwater ecosystems.mSystems · 2026Article
- TreeProfiler: large-scale metadata profiling along gene and species trees.Molecular biology and evolution · 2026Article
- Ultrasmall episymbiont Nanosynbacter lyticus employs multiple ATP-generating metabolic pathways during horizontal transmission.The ISME journal · 2026Article
- Shuyu Wan Potentiates PD-1 Inhibitor Efficacy in Non-Small Cell Lung Cancer: Integrated Bioinformatics and Experimental Evidence for Gut Microbiota-Tumor Immune Crosstalk.Drug design, development and therapy · 2026Article
- Groundwater microbial community structure under contrasting hydrological conditions in a sulfate-rich karst aquifer.Frontiers in microbiology · 2026Article
- Comprehensive evaluation of environment adaptability in wild and captive lenok (Frontiers in microbiology · 2026Article
- Taxonomic and Metagenomic Survey of a Peat-Based Straw Degrading Biofertilizer.Microorganisms · 2025Article
- Single-cell genomics reveals complex microbial and viral associations in ciliates and testate amoebae.Nature communications · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Patescibacteria, also known as the Candidate Phyla Radiation, are a diverse clade of largely uncultivated, small bacteria that comprise a significant proportion of all bacterial diversity. The few members that have been cultivated exhibit a fascinating life cycle in which they grow as obligate epibionts on the surface of host bacteria. In this Perspective, we make the case that the study of these unique, divergent, and poorly characterized organisms represents an exciting frontier in microbiology. This burgeoning field has already achieved several critical breakthroughs, including metagenomic sequence-based reconstructions of the metabolic and biosynthetic capabilities of diverse Patescibacteria and the development of generalizable strategies for their cultivation and genetic manipulation. We argue these that advances, among others, should pave the way toward a molecular understanding of the complex interactions that undoubtedly underpin the relationship between Patescibacteria and their hosts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.