Evidence map›Paper›PMID 39665547›Full record

ArticleJournal of virology2025

Novel lineage of anelloviruses with large genomes identified in dolphins.

Matthew D De Koch, Mart Krupovic, Russell Fielding, Kendal Smith, Kelsie Schiavone, Katharine R Hall, Vincent S Reid, Diallo Boyea, Emma L Smith, Kara Schmidlin and 5 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. ICTV Virus Taxonomy Profile:The Journal of general virology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. The Journal of general virology · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matthew D De KochThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Mart KrupovicInstitut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, Paris, France.ORCID 0000-0001-5486-0098
Russell FieldingHTC Honors College, Coastal Carolina University, Conway, South Carolina, USA.
Kendal SmithThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Kelsie SchiavoneDepartment of Earth and Environmental Systems, The University of the South, Sewanee, Tennessee, USA.
Katharine R HallDepartment of Earth and Environmental Systems, The University of the South, Sewanee, Tennessee, USA.
Vincent S ReidBarrouallie Whaler's Project, Barrouallie, Saint Vincent and the Grenadines.
Diallo BoyeaIndependent Researcher, Barrouallie, Saint Vincent and the Grenadines.
Emma L SmithDepartment of Chemical and Biological Sciences, The University of the West Indies at Cave Hill, Bridgetown, Saint Michael, Barbados.
Kara SchmidlinThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Rafaela S FonteneleThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Eugene V KooninNational Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, USA.ORCID 0000-0003-3943-8299
Darren P MartinComputational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Western Cape, South Africa.
Simona KrabergerThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Arvind VarsaniThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0003-4111-2415

Funding

NLM NIH HHS
6 · The paper itself

Abstract

Anellovirus infections are ubiquitous in mammals but lack any clear disease association, suggesting a commensal virus-host relationship. Although anelloviruses have been identified in numerous mammalian hosts, their presence in members of the family Delphinidae has yet to be reported. Here, using a metagenomic approach, we characterize complete anellovirus genomes ( IMPORTANCE: Anelloviruses are ubiquitous in mammals, but their infection has not yet been linked to any disease, suggesting a commensal virus-host relationship. Here, we describe the first anelloviruses associated with diverse species of dolphins. The dolphinid anelloviruses represent a new genus (tentatively named "Qoptorquevirus") and encode open reading frame 1 (ORF1) (capsid) proteins that are considerably larger than those encoded by previously described anelloviruses from other hosts. Comprehensive analysis of the ORF1 sequences and predicted protein structures revealed the underlying structural basis for such an extravagant ORF1 size and suggested that ORF1 size increased convergently in the anelloviruses associated with primate and Delphinidae hosts, respectively. Collectively, our results provide insights into the diversity and evolution of

Indexed as

AnelloviridaeDolphinsGenome, ViralAnimalsCapsid ProteinsOpen Reading FramesPhylogenyCapsid ProteinsAnelloviridaeDelphinidaefalse killer whalekiller whalepantropical spotted dolphinQoptorquevirusshort-finned pilot whalesingle jelly-roll fold

Identifiers

PMID39665547
PMCPMC11784456

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.