Evidence map›Paper›PMID 39665315›Full record

ReviewJournal of extracellular vesicles2024

A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research.

Sun Young Lee, Mikael Klingeborn, Jeff W M Bulte, Daniel T Chiu, Michael Chopp, Christopher W Cutler, Saumya Das, Charles E Egwuagu, Christie D Fowler, Sarah F Hamm-Alvarez and 10 more

Abstract readReview
In one paragraph

Review in Journal of extracellular vesicles, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sun Young LeeDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Mikael KlingebornMcLaughlin Research Institute, Great Falls, Montana, USA.ORCID 0000-0003-2907-0371
Jeff W M BulteDepartment of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Daniel T ChiuDepartment of Chemistry and Bioengineering, University of Washington, Seattle, Washington, USA.
Michael ChoppDepartment of Neurology, Henry Ford Health, Detroit, Michigan, USA.
Christopher W CutlerDepartment of Periodontics, Dental College of Georgia at Augusta University, Georgia, USA.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Charles E EgwuaguMolecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Christie D FowlerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.
Sarah F Hamm-AlvarezDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Hakho LeeCenter for System Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Yutao LiuDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Ben MeadSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, UK.
Tara L MooreDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Sriram RavindranDepartment of Oral Biology, College of Dentistry, University of Illinois Chicago, Chicago, Illinois, USA.
Ashok K ShettyInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University School of Medicine, College Station, Texas, USA.ORCID 0000-0001-5049-6671
Johan SkogExosome Diagnostics, a Bio-Techne Brand, Waltham, Massachusetts, USA.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ali R DjalilianDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Alissa M WeaverDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-4096-8636

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI Lilja Solnes · 2017 to 2026
$11.8M
Research Supplements to Promote DiversityR01EY011386 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAMM-ALVAREZ, SARAH F · 1996 to 2025
$9.3M
Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failureR35HL150807 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Saumya Das · 2020 to 2026
$6.7M
Protein-polymer nanomedicine for Sjogren's SyndromeR01EY026635 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sarah F Hamm-Alvarez, John Andrew MacKay · 2017 to 2026
$4.6M
Mesenchymal Stem Cell Derived Extracellular Vesicles for Traumatic Brain InjuryR01NS106907 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ASHOK K SHETTY · 2018 to 2026
$4.0M
Intranasal Treatment of Stem Cell-derived Extracellular Vesicles for Alzheimer's DiseaseRF1AG074256 · NIA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SHETTY, ASHOK K · 2022 to 2025
$3.6M
Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Gene Discovery in Familial KeratoconusR01EY023242 · NEI · DUKE UNIVERSITY · PI LIU, YUTAO · 2013 to 2023
$3.4M
Neural Stem Cell-derived EVs for Improving Aged Brain FunctionR01AG075440 · NIA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ASHOK K SHETTY · 2022 to 2026
$2.9M
3D Encapsulation, Bioprinting and Controlled Delivery of Functionally Engineered EVs (FEEs)R01DE030495 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COOPER, LYNDON F, GAJENDRAREDDY, PRAVEEN · 2021 to 2025
$2.3M
Mesenchymal stem cell extracellular vesicles for ischemic retinal damageR01EY033902 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI STEVEN ROTH, Sriram Ravindran · 2022 to 2026
$2.1M
Functional Activation and Targeting of Exosomes for Regenerative MedicineR01DE027404 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAJENDRAREDDY, PRAVEEN, RAVINDRAN, SRIRAM · 2018 to 2022
$2.1M
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY011386NEI NIH HHS R01 EY023242NEI NIH HHS R01 EY026635NEI NIH HHS R01 EY032960NEI NIH HHS R01 EY033902NEI NIH HHS R01 EY034193NEI NIH HHS R21 EY028671NEI NIH HHS R21 EY033961NEI NIH HHS R21 EY035425NHLBI NIH HHS R35 HL150807NIA NIH HHS R01 AG075440NIA NIH HHS RF1 AG074256NIBIB NIH HHS P41 EB024495NIDCR NIH HHS R01 DE027404NIDCR NIH HHS R01 DE030495NINDS NIH HHS R01 NS106907
6 · The paper itself

Abstract

With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. In 2021, the National Eye Institute (NEI) unveiled its Strategic Plan titled 'Vision for the Future (2021-2025),' which listed EV research as a priority within the domain of Regenerative Medicine, a pivotal area outlined in the Plan. In alignment with this prioritization, NEI organized a workshop inviting twenty experts from within and beyond the visual system. The workshop aimed to review current knowledge in EV research and explore gaps, needs and opportunities for EV research in the eye, including EV biology and applications of EVs in diagnosis, therapy and prognosis within the visual system. This perspective encapsulates the workshop's deliberations, highlighting the current landscape and potential implications of EV research in advancing eye health and addressing visual diseases.

Indexed as

Extracellular VesiclesNational Eye Institute (U.S.)AnimalsBiomedical ResearchEye DiseasesHumansUnited StatesVision, OculardiagnosisEVsexosomesEyeocularprognosistherapyvision

Identifiers

PMID39665315
PMCPMC11635481

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.