Evidence map›Paper›PMID 39665198›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Cardiac dysfunction and altered gene expression in acid ceramidase-deficient mice.

Annie Kleynerman, Jitka Rybova, William M McKillop, Theresa A Dlugi, Mary L Faber, Maria Fuller, Caitlin C O'Meara, Jeffrey A Medin

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Annie KleynermanDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-4878-5711
Jitka RybovaDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
William M McKillopDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Theresa A DlugiDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-4716-784X
Mary L FaberDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Maria FullerGenetics and Molecular Pathology, SA Pathology at Women's and Children's Hospital, Adelaide Medical School and School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0001-9092-8942
Caitlin C O'MearaDepartment of Physiology, Cardiovascular Center, and Genomics Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-9212-0821
Jeffrey A MedinDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0001-8165-8995

Funding

Medical Student Summer Research Training ProgramT35HL072483 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2003 to 2025
$3.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T35HL072483Midwest Athletes Against Childhood Cancer (MACC Fund)NHLBI NIH HHS T35 HL072483
6 · The paper itself

Abstract

Farber disease (FD) is an ultrarare, autosomal-recessive, lysosomal storage disorder attributed to

Indexed as

Acid CeramidaseCeramidesDisease Models, AnimalFarber LipogranulomatosisAnimalsCholesterolGene Expression RegulationHeart DiseasesLysosomesMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial ContractionMyocardiumMyocytes, CardiacAcid CeramidaseAsah1 protein, mouseCeramidesCholesterolSphingolipidsTroponin Icardiac developmentceramideFarber diseaselysosomal storage disorderneonatal

Identifiers

PMID39665198
PMCPMC12233101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.