Evidence map›Paper›PMID 39665190›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Single-Nucleus RNA Sequencing Reveals That Gabra6

Xiaowei Fei, Zehan Zhang, Ya-Nan Dou, Weihao Lv, Hongqing Chen, Li Wang, Xin He, Wangshu Chao, Peng Luo, Zhou Fei

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Single-Nucleus RNA Sequencing Reveals That Gabra6Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaowei FeiDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Zehan ZhangDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Ya-Nan DouDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Weihao LvDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Hongqing ChenDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Li WangDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Xin HeDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Wangshu ChaoDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Peng LuoDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.
Zhou FeiDepartment of Neurosurgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, 710032, China.ORCID https://orcid.org/0000-0003-3276-6345

Funding

National Key Research Development Program of China 2020-JCJQ-ZD-254-04
6 · The paper itself

Abstract

Shockwave-induced traumatic brain injury (TBI) results in the onset of post-traumatic stress disorder (PTSD), triggered either by the TBI itself or other stressors. However, the interplay and underlying mechanisms of how these factors synergistically induce PTSD remain inadequately elucidated. Here, mice in the TBI (induced by biological shock tube blast injury) and PTSD (induced by single prolonged stress method) groups both displayed symptoms of PTSD behaviors, with the TBI+PTSD (composite model) group exhibiting more severe manifestations. The result of snRNA-seq demonstrated a noticeable increase in the population of Gabra6

Indexed as

Brain Injuries, TraumaticNeuronsPrefrontal CortexReceptors, GABA-AStress Disorders, Post-TraumaticAnimalsDisease Models, AnimalDisease ProgressionMaleMiceMice, Inbred C57BLReceptors, GABA-AcAMP signalingGabra6PTSDsingle‐nucleus RNA sequencingTBI

Identifiers

PMID39665190
PMCPMC11792052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.