Evidence map›Paper›PMID 39665036›Full record

ReviewFrontiers in reproductive health2024

Ecology meets reproductive medicine in HIV prevention: the case for geography-informed approaches for bacterial vaginosis in Africa.

Jo-Ann S Passmore, Sinaye Ngcapu, Serah Gitome, Brian R Kullin, Kirsten Welp, Darren P Martin, Disebo Potloane, Monalisa T Manhanzva, Moses M Obimbo, Katherine Gill and 5 more

Abstract readReview
In one paragraph

Review in Frontiers in reproductive health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jo-Ann S PassmoreInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Sinaye NgcapuCentre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa.
Serah GitomeCentre for Microbiology Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Brian R KullinInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Kirsten WelpInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Darren P MartinInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Disebo PotloaneCentre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa.
Monalisa T ManhanzvaInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Moses M ObimboDepartment of Human Anatomy and Medical Physiology, University of Nairobi, Nairobi, Kenya.
Katherine GillInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Mellissa Le FevreDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Anna-Ursula HappelInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Heather B JaspanInstitute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Margaret KasaroUniversity of North Carolina Global Projects Zambia, Lusaka, Zambia.
Elizabeth A BukusiCentre for Microbiology Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

Funding

Gates Foundation INV-037612
6 · The paper itself

Abstract

Purpose of review: Women in Africa bear the burden of the HIV epidemic, which has been associated with the high prevalence of bacterial vaginosis (BV) in the region. However, little progress has been made in finding an effective cure for BV. Drawing on advances in microbiome-directed therapies for gastrointestinal disorders, similar live-biotherapeutic based approaches for BV treatment are being evaluated. Here, we summarize current knowledge regarding vaginal microbiota in BV, explore geographical differences in vaginal microbiota, and argue that novel BV therapeutics should be tailored specifically to meet the needs of African women. Recent findings: Cervicovaginal microbiota dominated by Summary: Improving the efficacy and durability of BV treatment with microbiome-directed therapies by appropriately accounting for host and microbial genetic factors, could potentially reduce the risk of HIV infection in African women.

Indexed as

Africabacterial vaginosisfemalegeographyHIVhost geneticsinflammationprobiotics

Identifiers

PMID39665036
PMCPMC11631894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.