ArticleFrontiers in chemistry2024
Antioxidant potential, antimicrobial activity, polyphenol profile analysis, and cytotoxicity against breast cancer cell lines of hydro-ethanolic extracts of leaves of (
Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Chitosan-Based Nanocarriers Co-Delivering Pioglitazone and Curcumin: Biological Activity and Therapeutic Potential in Diabetes.International journal of molecular sciences · 2026Article
- Fig Leaf Bioactivity and Safety: Temperature Optimization and FTIR Authentication.Food science & nutrition · 2026Article
- Maturation-Associated Physiological and Biochemical Transitions in Carob (Ceratonia siliqua L.): Optimizing Harvest Timing Toward Functional Valorization of Fruits.TheScientificWorldJournal · 2026Article
- Effects of Common Fig (International journal of molecular sciences · 2025Review
- Phytochemical characterization and biological activities of wild Ceratonia siliqua L. leaves: antioxidant, antibacterial, and cytotoxic effects.Scientific reports · 2025Article
- Nutritional value antioxidant strength and antimicrobial efficacy of fig pastes from eastern morocco.Scientific reports · 2025Article
- Nutritional composition health benefits and quality of fresh and dried figs from Eastern Morocco.Scientific reports · 2025Article
- Article
- OverallFrontiers in microbiology · 2025Article
- Bioactive Compounds From Saudi Arabian Fungi: A Systematic Review of Anticancer Potential.Clinical pharmacology : advances and applications · 2025Review
- Nutritional value, HPLC-DAD analysis and biological activities of Ceratonia siliqua L. pulp based on in vitro and in silico studies.Scientific reports · 2024Article
- In vitro evaluation of color characterization, mechanical properties, and antimicrobial activity of 3D-printed provisional dental resin incorporated with Ficus carica (Fig) seed extract.Journal of oral biology and craniofacial researchArticle
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Abstract
Introduction: Many beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities. Methods results and discussion: HPLC-UV examination revealed that the leaf extract included mainly caffeine, rutin, and ferrulic acid. Spectrophometric results show that Malha leaf is rich in polyphenols (62.6 ± 1.3 mg GAE/g) and flavonoids (26.2 ± 0.1 mg QE/g). Chetoui leaf contains the highest vitamin C content (8.2 ± 0.1 mg Asc A/100 g DW), while Onk Hmam leaf has the highest condensed tannin (4.9 ± 0.1 mg CatE/g). The investigations found that all leaf extracts were antioxidant-rich, with strong Pearson bivariate correlation between bioactive polyphenol levels and antioxidant tests for DPPH, β-carotene, ABTS, and TAC (values of -0.93, -0.94, -0.85, and 0.98, respectively). The coefficients for flavonoid content were -0.89, -0.89, -0.97, and 0.80, respectively. Disk diffusion and MIC results show that the hydro-ethanol fig leaf extracts eliminate fungi and bacteria. In addition, these fig leaf extracts showed promise cytotoxicity against the breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-436 and an interesting selectivity index. In silico leaf bioactive component analysis revealed that myricitin inhibited NADPH oxidase the greatest (gscore -6.59 Kcal/mol). Trans-ferulic acid inhibits Escherichia coli beta-ketoacyl-[acyl carrier protein] synthase (-6.55 kcal/mol), whereas quercetin inhibits Conclusion: This research indicates that fig leaf extracts from the region can be used in medicine, food, natural cosmetics, and breast cancer prevention. To maximize the value of these leaves, their use must be carefully studied. Naturally, this fortunate tree's diversity must be preserved and enhanced.
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