ArticleFrontiers in systems neuroscience2024
Effect of chewing hard material on boosting brain antioxidant levels and enhancing cognitive function.
Article in Frontiers in systems neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Glutamate-Glutathione axis in neuropsychiatric disorders and cancer: From shared mechanisms to non-invasive biomarkers.Redox biology · 2026Review
- Association between reduced chewing-induced brain blood flow and cognitive performance in mandibular prognathism patients in a pilot study.Scientific reports · 2026Article
- Association Between Gum Chewing and Temporomandibular Disorders.Journal of clinical medicine · 2025Article
- The Neural Correlates of Chewing Gum-A Neuroimaging Review of Its Effects on Brain Activity.Brain sciences · 2025Review
- The Occlusal Contact Area Is Associated with the Magnitude but Not Peak Timing of Changes in Chewing-Induced Brain Blood Flow in Mandibular Prognathism.Dentistry journal · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Chewing has been reported to enhance cognitive function through the increase in cerebral blood flow. However, the mechanisms linking cerebral blood flow increase to metabolic changes in the brain affecting cognition remain unclear. We hypothesized that glutathione (GSH) plays a pivotal role in these mechanisms. Therefore, this study aimed to investigate changes in brain GSH levels following chewing and their association with cognitive function in healthy young adults. Methods: A total of 52 university students were recruited, and the Korean version of the Repeatable Battery for the Assessment of Neuropsychological Status was used for the neurocognitive evaluations. Brain GSH levels following chewing gum or wood blocks were measured using MEscher-GArwood Point RESolved Spectroscopy (MEGA-PRESS) sequence, and their relevance to neurocognitive evaluation results was investigated. Results: Chewing significantly increased brain GSH concentration, particularly in the wood-chewing group compared to the gum-chewing group, as observed in the anterior cingulate cortex. Furthermore, the rise in GSH concentration in the wood-chewing group was positively correlated with memory function. Conclusion: Chewing moderately hard material elevates brain antioxidant levels such as GSH, potentially influencing cognitive function.
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