Evidence map›Paper›PMID 39664680›Full record

ArticleNeuro-oncology advances

Added prognostic value of DCE blood volume imaging in patients with suspected recurrent or residual glioblastoma-A hybrid [

Otto Mølby Henriksen, Aida Muhic, Michael Juncker Lundemann, Henrik Bo Wiberg Larsson, Ulrich Lindberg, Thomas Lund Andersen, Benedikte Hasselbalch, Søren Møller, Lisbeth Marner, Karine Madsen and 4 more

Abstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The confounding effects of microvascular physiology on the uptake and diagnostic accuracy of [European journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Otto Mølby HenriksenDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0009-0004-0472-015X
Aida MuhicDepartment of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Michael Juncker LundemannDepartment of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Henrik Bo Wiberg LarssonDepartment of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Ulrich LindbergDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Thomas Lund AndersenDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Benedikte HasselbalchDepartment of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Søren MøllerDepartment of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Lisbeth MarnerDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5843-5742
Karine MadsenDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Vibeke Andrée LarsenDepartment of Radiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Hans Skovgaard PoulsenThe DCCC Brain Tumor Center, Danish Comprehensive Cancer Center, Copenhagen, Denmark.
Adam Espe HansenDepartment of Radiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Ian LawDepartment of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Magnetic resonance imaging (MRI) cerebral blood volume (CBV) measurements improve the diagnosis of recurrent gliomas. The study investigated the prognostic value of dynamic contrast-enhanced (DCE) CBV imaging in treated IDH wildtype glioblastoma when added to MRI or amino acid positron emission tomography (PET). Methods: Hybrid [ Results: Adjusted for methyltransferase gene status and steroid use all total tumor volumes were individually associated with shorter OS. Adding VOL Conclusions: The high CBV tumor volume was a strong prognosticator of survival and allowed for the separation of high- and low-risk subvolumes underlining the heterogeneous physiological environment represented in the contrast-enhancing or metabolically active tumor volumes of treated glioblastoma.

Indexed as

blood volumeglioblastomamagnetic resonance imagingperfusion imagingprognosis

Identifiers

PMID39664680
PMCPMC11632823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.