Evidence map›Paper›PMID 39664587›Full record

ArticleInternational journal of biological sciences2024

Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.

Wenxin Qi, Yiwei Ying, Peiru Wu, Naijun Dong, Wenjun Fu, Qian Liu, Natalie Ward, Xin Dong, Robert Chunhua Zhao, Jiao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Food science & nutrition · 2026
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenxin QiSchool of Life Sciences, Shanghai University, Shanghai, China.
Yiwei YingSchool of Life Sciences, Shanghai University, Shanghai, China.
Peiru WuSchool of Life Sciences, Shanghai University, Shanghai, China.
Naijun DongSchool of Life Sciences, Shanghai University, Shanghai, China.
Wenjun FuSchool of Life Sciences, Shanghai University, Shanghai, China.
Qian LiuSchool of Life Sciences, Shanghai University, Shanghai, China.
Natalie WardBanner Ocotillo Medical Center, 1405 S Alma School Rd, Chandler, AZ 85286, USA.
Xin DongSchool of Medicine, Shanghai University, Shanghai, China.
Robert Chunhua ZhaoSchool of Life Sciences, Shanghai University, Shanghai, China.
Jiao WangSchool of Life Sciences, Shanghai University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline and memory impairment are subsequently result in neuronal apoptosis and synaptic damage. Aberrant regulation of microRNAs has been implicated in the pathogenesis of Alzheimer's disease (AD) and may play a pivotal role in the early stages of the disease. In this study, we identified the critical role of miR-4763-3p in AD pathogenesis, focusing on early-stage mild cognitive impairment (AD-MCI). Leveraging fluorescence

Indexed as

Alzheimer DiseaseAutophagyCognitive DysfunctionMicroRNAsPhosphatidylinositol 3-KinasesSignal TransductionTOR Serine-Threonine KinasesAnimalsApoptosisHippocampusHumansMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-bcl-2MicroRNAsmTOR protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-bcl-2TOR Serine-Threonine KinasesAD-MCIapoptosisautophagyphosphatidylserine

Identifiers

PMID39664587
PMCPMC11628338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.