Evidence map›Paper›PMID 39664579›Full record

ArticleInternational journal of biological sciences2024

Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through

Yunhuan Gao, Jianmei Yue, Fushuang Ha, Ya Wang, Rong Wang, Xiaorong Yang, Junqi Zhang, Xinqi Liu, Yuan Zhang, Tao Han and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Biological Actions of Bile Acids via Cell Surface Receptors.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunhuan GaoTranslational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Tianjin 300071, China.
Jianmei YueTranslational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Tianjin 300071, China.
Fushuang HaThe Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China.
Ya WangDepartment of Immunology, Nankai University School of Medicine; Nankai University, Tianjin 300071, China.
Rong WangDepartment of Immunology, Nankai University School of Medicine; Nankai University, Tianjin 300071, China.
Xiaorong YangDepartment of Immunology, Nankai University School of Medicine; Nankai University, Tianjin 300071, China.
Junqi ZhangCollege of life Science, Nankai University, Tianjin, China, Tianjin 300121, China.
Xinqi LiuCollege of life Science, Nankai University, Tianjin, China, Tianjin 300121, China.
Yuan ZhangDepartment of Immunology, Nankai University School of Medicine; Nankai University, Tianjin 300071, China.
Tao HanTianjin Union Medical Center, Tianjin Medical University, Tianjin 300270, China.
Rongcun YangTranslational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Tianjin 300071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipopolysaccharide (LPS) mediated caspases-4 (humans) and caspase-11 (rodent) (caspase-4/11) signaling can cause maturation of inflammatory cytokine IL-1β and cellular pyroptosis in the macrophages through guanylate-binding proteins (GBPs). However, how caspase-4/11s bind with GBPs together to activate caspase-4/11 by LPS remains elusive. We here found that BA derivatives from gut microbiota can regulate sensitivity of macrophages to LPS and Gram-negative bacteria through

Indexed as

Bile Acids and SaltsCaspasesCaspases, InitiatorGastrointestinal MicrobiomeLipopolysaccharidesAnimalsGTP-Binding ProteinsHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutRNA, Long NoncodingBile Acids and Saltscaspase 11, humanCaspasesCaspases, InitiatorGTP-Binding ProteinsLipopolysaccharidesRNA, Long Noncodingcaspase-4/11guanylate-binding protein 1lncRNA57RIKmacrophagessphingosine-1-phosphate receptor 2

Identifiers

PMID39664579
PMCPMC11628326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.