Evidence map›Paper›PMID 39664418›Full record

ArticleActa pharmaceutica Sinica. B2024

GPR17 modulates anxiety-like behaviors

Ruizhe Nie, Xinting Zhou, Jiaru Fu, Shanshan Hu, Qilu Zhang, Weikai Jiang, Yizi Yan, Xian Cao, Danhua Yuan, Yan Long and 2 more

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruizhe NieDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Xinting ZhouDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Jiaru FuDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Shanshan HuDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Qilu ZhangDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Weikai JiangDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yizi YanDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Xian CaoDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Danhua YuanDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yan LongDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Hao HongDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Susu TangDepartment of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety disorders are one of the most epidemic and chronic psychiatric disorders. An incomplete understanding of anxiety pathophysiology has limited the development of highly effective drugs against these disorders. GPR17 has been shown to be involved in multiple sclerosis and some acute brain injury disorders. However, no study has investigated the role of GPR17 in psychiatric disorders. In a well-established chronic restraint stress (CRS) mouse model, using a combination of pharmacological and molecular biology techniques, viral tracing,

Indexed as

AnxietyBasolateral amygdalaCangrelorCRSGlutamatergic neuronsGlutamatergic projectionGPR17Ventral hippocampal CA1

Identifiers

PMID39664418
PMCPMC11628806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.