ArticleCureus2024
Use of Hyaluronic Acid Hybrid Complex to Treat Wrinkles in the Upper Third of the Face: A Case Report.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Botulinum Toxin Treatment Can Enlarge Eye Appearance in Asian Patients and Improves Social and Emotional Attributes.Toxins · 2026Article
- Hyaluronic Acid ProfhiloMedicina (Kaunas, Lithuania) · 2026Article
- Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical changes, such as skin atrophy, loss of elasticity, and the appearance of fine lines and wrinkles, are common during aging. A hybrid hyaluronic acid (HA) complex containing both low and high molecular weight has shown promising results in promoting skin restructuring by remodeling the epidermis, dermis, and hypodermis. This study describes three cases of facial aging, each with unique challenges. The upper third of the face was treated with two sessions spaced 30 days apart of hybrid HA using the blanching technique. These cases highlight the pressing need for alternative treatments that regenerate new tissues and cells, leading to a new skin architecture, as the use of neuromodulators in isolation can lead to unwanted side effects. The recovery of extracellular matrix proteins in this region with hybrid HA has significantly improved the elasticity, firmness, texture, and hydration of the skin, providing a healthier appearance and reducing the quantity and depth of facial wrinkles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.