ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Images: Combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea.
Jonathan Mitton, Muhammad E Khan, Daniel Combs, Sairam Parthasarathy, Saif Mashaqi
Abstract readCase Reports
In one paragraphArticle in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
5 authors.
Jonathan MittonDepartment of Pediatrics, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.
Muhammad E KhanDepartment of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.
Daniel CombsThe University of Arizona Health Sciences Center for Sleep & Circadian Sciences, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.
Sairam ParthasarathyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Sleep & Circadian Sciences, University of Arizona Health Sciences, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.
Saif MashaqiDepartment of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.
Funding
Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)U01HL128954 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCIURBA, FRANK, WISNIEWSKI, STEPHEN R · 2015 to 2019
$17.0MSleep and Cardiometabolic Health Disparities at the US/Mexico Border: The Nogales Cardiometabolic Health and Sleep (NoCHeS) StudyR01MD011600 · NIMHD · UNIVERSITY OF ARIZONA · PI GRANDNER, MICHAEL A · 2018 to 2022
$4.1MMedications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS)R33HL151254 · NHLBI · UNIVERSITY OF ARIZONA · PI COMBS, DANIEL · 2022 to 2025
$1.3MPredictive Analytics and Peer-Driven Intervention for Guideline-based Care for Sleep ApneaR56HL138377 · NHLBI · UNIVERSITY OF ARIZONA · PI PARTHASARATHY, SAIRAM · 2017 to 2017
$763kImpact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UG3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2018 to 2018
$742kMedications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS)R61HL151254 · NHLBI · UNIVERSITY OF ARIZONA · PI COMBS, DANIEL · 2019 to 2021
$465kDEtermining Capacity and Informing Down syndrome Assent Strategies (DECIDAS)R21HD109777 · NICHD · UNIVERSITY OF ARIZONA · PI COMBS, DANIEL · 2022 to 2023
$422kNHLBI NIH HHS R33 HL151254NHLBI NIH HHS R56 HL138377NHLBI NIH HHS R61 HL151254NHLBI NIH HHS U01 HL128954NHLBI NIH HHS UG3 HL140144NICHD NIH HHS R21 HD109777NIMHD NIH HHS R01 MD011600
6 · The paper itselfAbstract
Obstructive sleep apnea is one of the most common sleep disorders. Positive airway pressure therapy is considered the gold standard for treating obstructive sleep apnea. Yet, optimal therapy might not be achieved in some cases of severe obstructive sleep apnea, despite using maximum settings. In this case report, we describe the successful combination of positive airway pressure therapy and atomoxetine-oxybutynin in reducing the apnea-hypopnea index from the severe range to the mild to moderate range. This was also associated with significant improvement in several symptoms including excessive daytime sleepiness and drowsiness while driving. CITATION: Mitton J, Khan ME, Combs D, Parthasarathy S, Mashaqi S. Images: combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea.
Indexed as
Atomoxetine HydrochlorideContinuous Positive Airway PressureMandelic AcidsSleep Apnea, ObstructiveAdrenergic Uptake InhibitorsCombined Modality TherapyHumansPolysomnographySeverity of Illness IndexTreatment OutcomeAdrenergic Uptake InhibitorsAtomoxetine HydrochlorideMandelic Acidsoxybutyninapnea-hypopnea indexatomoxetine-oxybutynincombination therapydrug-induced sleep endoscopyobstructive sleep apnea
Identifiers
PMID39663915
PMCPMC11965088
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