Evidence map›Paper›PMID 39663899›Full record

ArticleACS applied materials & interfaces2024

pH-Dependent Conformational Plasticity of Monoclonal Antibodies at the SiO

Zongyi Li, Suman Saurabh, Peter Hollowell, Cavan K Kalonia, Thomas A Waigh, Peixun Li, John R P Webster, John M Seddon, Fernando Bresme, Jian Ren Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zongyi LiBiological Physics Group, School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.ORCID 0000-0002-5989-9132
Suman SaurabhDepartment of Chemistry, Molecular Sciences Research Hub Imperial College, London W12 0BZ, United Kingdom.
Peter HollowellBiological Physics Group, School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Cavan K KaloniaDosage Form Design and Development, BioPharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States.
Thomas A WaighBiological Physics Group, School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.ORCID 0000-0002-7084-559X
Peixun LiSTFC ISIS Facility, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom.ORCID 0000-0002-7749-1472
John R P WebsterSTFC ISIS Facility, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom.
John M SeddonDepartment of Chemistry, Molecular Sciences Research Hub Imperial College, London W12 0BZ, United Kingdom.
Fernando BresmeDepartment of Chemistry, Molecular Sciences Research Hub Imperial College, London W12 0BZ, United Kingdom.ORCID 0000-0001-9496-4887
Jian Ren LuBiological Physics Group, School of Physics and Astronomy, Faculty of Science and Engineering, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.ORCID 0000-0001-5648-3564

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Investigating the molecular conformations of monoclonal antibodies (mAbs) adsorbed at the solid/liquid interface is crucial for understanding mAb solution stability and advancing the development of mAb-based biosensors. This study examines the pH-dependent conformational plasticity of a human IgG1k mAb, COE-3, at the SiO

Indexed as

Antibodies, MonoclonalMolecular Dynamics SimulationSilicon DioxideWaterAdsorptionHumansHydrogen-Ion ConcentrationImmunoglobulin GNeutronsProtein ConformationAntibodies, MonoclonalImmunoglobulin GSilicon DioxideWatermolecular dynamics (MD)monoclonal antibodies (mAbs)neutron reflection (NR)protein adsorptionprotein therapeutics

Identifiers

PMID39663899
PMCPMC11672230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.