ArticleAdvanced healthcare materials2025
Specific gFET-Based Aptasensors for Monitoring of Microbiome Quality: Quantification of the Enteric Health-Relevant Bacterium Roseburia Intestinalis.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Single-sequence based gFET-aptasensors for the discrimination of apo- and holo-RBP4 in human serum.Scientific reports · 2026Article
- Aptamer-Based Biosensors for Rapid Detection and Early Warning of Food Contaminants: From Selection to Field Applications.Molecules (Basel, Switzerland) · 2025Review
- An Aptamer-Based gFET-Sensor for Specific Quantification of Gene Therapeutic Human Adenovirus Type 5.Biosensors · 2025Article
- The Power of Old Hats: Rediscovering Inosine-EpPCR to Create Starting Libraries for Whole-Cell-SELEX.Biosensors · 2025Article
- Specific gFET-Based Aptasensors for Monitoring of Microbiome Quality: Quantification of the Enteric Health-Relevant Bacterium Roseburia Intestinalis.Advanced healthcare materials · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
Roseburia intestinalis, enriched in the gut, is closely associated with obesity, intestinal inflammation, and other diseases. A novel detection method for R. intestinalis to replace the commonly used 16S rRNA sequencing technique is aim to developed, thus enabling real-time and low-cost monitoring of gut microbiota. The optimal solution is to utilize rGO-FET (reduced graphene oxide field-effect transistor) functionalized with aptamers. Due to the high sensitivity of graphene sensors to electronic changes in the system, it is anticipated to achieve detection sensitivity that traditional fluorescence detection techniques cannot attain. The previous work reported a nucleic acid aptamer library, Ri 7_2, capable of quantitatively tracking R. intestinalis in complex systems. However, due to the complexity of the aptamer library itself, large-scale industrial synthesis is challenging, significantly limiting its further commercial application potential. Therefore, in this study, through Next-Generation Sequencing analysis, four representative single aptamers from the aptamer library is strategically selected, named A-Rose 1, A-Rose 2, A-Rose 3, and A-Rose 4, and confirmed their excellent performance similar to the aptamer library Ri 7_2. Furthermore, aptamer-modified rGO-FET demonstrated universality in detecting R. intestinalis in a series of biochemical analyses, providing a novel and powerful diagnostic tool for the clinical diagnosis of R. intestinalis.
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Registered trials
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