Evidence map›Paper›PMID 39663556›Full record

ArticleACS infectious diseases2025

Testing the Antigenic Potential of Transmembrane Proteins To Develop a Thermostable Tuberculosis MOF-Liposomal Vaccine.

Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Angelo Izzo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A copper uptake ABC transport system is essential forEmerging microbes & infections · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sneha KumariDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0002-5245-7016
Jonathan Martinez-GarciaDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0009-0009-9344-0630
Ryanne Nicole EhrmanDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Wendy TangDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Joshua MilesDepartment of Immunology, UT Southwestern Medical Center, Dallas, Texas 75390, United States.
Priyanka BasakDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0001-6181-5113
Thomas Sinclair HowlettDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Yalini Hansika WijesundaraDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Ziqi WangDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.
Angelo IzzoCentenary Institute, University of Sydney, Sydney, NSW2050, Australia.
Blanca RestrepoSchool of Public Health at Brownsville, University of Texas Health Science Center at Houston, Brownsville, Texas 78520, United States.
Lenette LuDepartment of Immunology, UT Southwestern Medical Center, Dallas, Texas 75390, United States.
Gabriele MeloniDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0003-4976-1401
Jeremiah J GassensmithDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0001-6400-8106

Funding

INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5M
Defining the antibody interface between Mycobacterium tuberculosis and host immunityR01AI158858 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI LU, LENETTE · 2021 to 2025
$2.1M
NIAID NIH HHS R01 AI158858NIAID NIH HHS T32 AI005284NIGMS NIH HHS R35 GM128704
6 · The paper itself

Abstract

Tuberculosis is one of the deadliest infectious diseases and continues to be a major health risk in many parts of the world. Even today, the century-old Bacillus Calmette-Guerin (BCG) vaccine is the only formulation on the market and is ineffective for several sections of the global population responsible for transmission. In the search for antigens that can mount a robust immune response, we have reported the recombinant expression and purification of two novel membrane proteins, the Cation transporter protein V (CtpV) and the Mycobacterial copper transporter B (MctB) present on the membrane surface of

Indexed as

Antigens, BacterialLiposomesMycobacterium tuberculosisTuberculosisTuberculosis VaccinesAdjuvants, ImmunologicAnimalsBacterial ProteinsCation Transport ProteinsFemaleHumansMembrane ProteinsMiceMice, Inbred C57BLProteolipidsAdjuvants, ImmunologicAntigens, BacterialBacterial ProteinsCation Transport ProteinsLiposomesMembrane ProteinsProteolipidsproteoliposomesTuberculosis Vaccinesbiomimetic mineralizationintranasal deliverymembrane protein antigensmetal−organic frameworkstuberculosis vaccine

Identifiers

PMID39663556
PMCPMC12377458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.