Evidence map›Paper›PMID 39663496›Full record

ArticleNature2024

Continuous collective analysis of chemical reactions.

Maowei Hu, Lei Yang, Nathaniel Twarog, Jason Ochoada, Yong Li, Eirinaios I Vrettos, Arnaldo X Torres-Hernandez, James B Martinez, Jiya Bhatia, Brandon M Young and 10 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Generalized Analysis of Electrophilic Small Molecules.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. A General Group Testing Strategy for Discovering Chemical Cooperativity.Angewandte Chemie (International ed. in English) · 2026
    Article
  6. Direct-to-Biology Enabled Molecular Glue Discovery.Journal of the American Chemical Society · 2026
    Article
  7. Considerations in Pursuing Reaction Scope Generality.Angewandte Chemie (International ed. in English) · 2025
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Maowei HuDepartment of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9317-3749
Lei YangAnalytical Technologies Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Nathaniel TwarogLead Discovery Informatics Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Jason OchoadaLead Discovery Informatics Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Yong LiAnalytical Technologies Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Eirinaios I VrettosDepartment of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Arnaldo X Torres-HernandezDepartment of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0009-4791-8891
James B MartinezDepartment of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-9881-5555
Jiya BhatiaDepartment of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3268-9714
Brandon M YoungMedicinal Chemistry Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2973-2072
Jeanine PriceMedicinal Chemistry Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Kevin McGowanMedicinal Chemistry Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Theresa H NguyenMedicinal Chemistry Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Zhe ShiMedicinal Chemistry Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Matthew AnyanwuLead Discovery Informatics Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Mary Ashley RimmerAnalytical Technologies Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Shea MercerProgram Management, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Zoran RankovicAnalytical Technologies Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.
Anang A ShelatLead Discovery Informatics Center, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6266-2910
Daniel J BlairDepartment of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, TN, USA. Daniel.Blair@stjude.org.ORCID http://orcid.org/0000-0002-2279-7538

Funding

PROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3M
Graduate Training at the Biology-Chemistry InterfaceT32GM132061 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Brian Douglas Ackley · 2020 to 2026
$2.9M
NCI NIH HHS R25 CA023944NIGMS NIH HHS T32 GM132061
6 · The paper itself

Abstract

The automated synthesis of small organic molecules from modular building blocks has the potential to transform our capacity to create medicines and materials

Identifiers

PMID39663496
PMCPMC11823688

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.