ReviewNature2024
π-HuB: the proteomic navigator of the human body.
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Review in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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22citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Population proteomics for equitable precision medicine.EMBO molecular medicine · 2026Article
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Article
- Plasma proteomic signatures of early retinal neurodegeneration in diabetes: A multi-cohort study.PLoS medicine · 2026Observational
- Extracellular vesicle and particle biomarkers in cancer: a machine learning blueprint for liquid biopsy.Journal of nanobiotechnology · 2026Review
- Interpretable deep learning framework for mapping E3-substrate binding interfaces.Nature communications · 2026Article
- Proteoforms as the true units of physiological function.European journal of applied physiology · 2026Review
- Inflammasomes meet organoids and artificial intelligence: unraveling the complexity of gynecological inflammation.Frontiers in immunology · 2026Review
- Genome agnostic, multi-level non-oncogene addiction-based systems pharmacology for rescuing metastatic relapsed/refractory neoplasias.Frontiers in pharmacology · 2026Review
- Large language models for clinical decision support in gastroenterology and hepatology.Nature reviews. Gastroenterology & hepatology · 2025Review
- Towards unmanned proteomics data generation: a fully automated sample-to-data system for proteomic experiments.Cell discovery · 2025Article
- State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025Review
- Federated Deep Learning Enables Cancer Subtyping by Proteomics.Cancer discovery · 2025Article
- LocPro: A deep learning-based prediction of protein subcellular localization for promoting multi-directional pharmaceutical research.Journal of pharmaceutical analysis · 2025Article
- The coming era of proteomics-driven precision medicine.National science review · 2025Review
- Proteomics in pancreatic cancer.Biomarker research · 2025Review
- A Comparative Proteomics Study of Autopsy and Fresh-Frozen Coronary Artery Samples.Journal of proteome research · 2025Article
- Enhancing the breeding gene pool of wheat using accessions in gene banks as demonstrated by the Watkins collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Unraveling Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Use of Omics Technologies.International journal of molecular sciences · 2025Review
- Review
Corrections and comments
- Erratum issued
Authors and funding
102 authors.
Fuchu HeState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. hefc@bmi.ac.cn.ORCID 0000-0002-8571-2351
Ruedi AebersoldDepartment of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. aebersold@imsb.biol.ethz.ch.ORCID 0000-0002-9576-3267
Mark S BakerMacquarie Medical School, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0001-5858-4035
Xiuwu BianInstitute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China.ORCID 0000-0003-4383-0197
Xiaochen BoInstitute of Health Service and Transfusion Medicine, Beijing, China.ORCID 0000-0003-3490-5812
Daniel W ChanDepartment of Pathology and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
Cheng ChangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.ORCID 0000-0002-0361-2438
Luonan ChenKey Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-3960-0068
Xiangmei ChenDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, China.
Yu-Ju ChenInstitute of Chemistry, Academia Sinica, Taipei, China.ORCID 0000-0002-3178-6697
Heping ChengNational Biomedical Imaging Center, State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, College of Future Technology, Peking University, Beijing, China.ORCID 0000-0002-9604-6702
Ben C CollinsSchool of Biological Sciences, Queen's University of Belfast, Belfast, UK.ORCID 0000-0003-0827-3495
Fernando CorralesFunctional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Madrid, Spain.ORCID 0000-0002-0231-5159
Jürgen CoxComputational Systems Biochemistry Research Group, Max-Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0001-8597-205X
Weinan EAI for Science Institute, Beijing, China.
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-9050-148X
Jia FanDepartment of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-5158-629X
Pouya FaridiCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia.ORCID 0000-0002-2712-3356
Daniel FigeysSchool of Pharmaceutical Sciences and Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0002-5373-7546
George Fu GaoThe D. H. Chen School of Universal Health, Zhejiang University, Hangzhou, China.ORCID 0000-0002-3869-615X
Wen GaoPengcheng Laboratory, Shenzhen, China.ORCID 0000-0001-8894-1806
Zu-Hua GaoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-7232-0933
Keisuke GodaDepartment of Chemistry, University of Tokyo, Tokyo, Japan.ORCID 0000-0001-6302-6038
Wilson Wen Bin GohLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Dongfeng GuSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Changjiang GuoDepartment of Nutrition, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.
Tiannan GuoSchool of Medicine, Westlake University, Hangzhou, China.ORCID 0000-0003-3869-7651
Yuezhong HeInternational Academy of Phronesis Medicine (Guangdong), Guangdong, China.
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-2405-4404
Henning HermjakobEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.ORCID 0000-0001-8479-0262
Tony HunterMolecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-7691-6993
Narayanan Gopalakrishna IyerDepartment of Head & Neck Surgery, Division of Surgery & Surgical Oncology, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.ORCID 0000-0002-8812-6219
Ying JiangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.ORCID 0000-0001-9524-0370
Connie R JimenezOncoProteomics Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Lokesh JoshiAdvanced Glycoscience Research Cluster, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.ORCID 0000-0002-3612-0747
Neil L KelleherDepartments of Molecular Biosciences, Departments of Chemistry, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-8815-3372
Ming LiDavid R. Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada.
Yang LiState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Qingsong LinDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9117-8514
Cui Hua LiuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-8035-7792
Fan LiuDepartment of Structural Biology, Leibniz-Forschungsinstitut für MolekularePharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-2358-549X
Guang-Hui LiuState Key Laboratory of Membrane Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-9289-8177
Yansheng LiuCancer Biology Institute, Yale University School of Medicine, West Haven, CT, USA.ORCID 0000-0002-2626-3912
Zhihua LiuState Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0003-4242-033X
Teck Yew LowUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.ORCID 0000-0001-7878-7534
Ben LuDepartment of Critical Care Medicine and Hematology, The Third Xiangya Hospital, Central South University; Department of Hematology and Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-8597-0406
Matthias MannProteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0003-1292-4799
Anming MengSchool of Life Sciences, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing, China.ORCID 0000-0001-7228-3431
Robert L MoritzInstitute for Systems Biology, Seattle, WA, USA.
Edouard NiceClinical Biomarker Discovery and Validation, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-5480-4715
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gilbert S OmennCenter for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8976-6074
Christopher M OverallDepartment of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-5844-2731
Giuseppe PalmisanoGlycoproteomics Laboratory, Department of Parasitology, University of São Paulo, Sao Paulo, Brazil.ORCID 0000-0003-1336-6151
Yaojin PengInstitute of Zoology, Chinese Academy of Sciences, Beijing, China.
Charles PineauInstitut de Recherche en Santé Environnement et Travail, Univ. Rennes, Inserm, EHESP, Irset, Rennes, France.
Terence Chuen Wai PoonPilot Laboratory, MOE Frontier Science Centre for Precision Oncology, Centre for Precision Medicine Research and Training, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau, China.
Anthony W PurcellInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0003-0532-8331
Jie QiaoState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.ORCID 0000-0003-2126-1376
Roger R ReddelProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0002-6302-6107
Phillip J RobinsonProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0002-7878-0313
Paola RoncadaDepartment of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.
Chris SanderDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Jiahao ShaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.ORCID 0000-0002-4807-7547
Erwei SongGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID 0000-0002-5400-9049
Sanjeeva SrivastavaIndian Institute of Technology Bombay, Mumbai, India.ORCID 0000-0001-5159-6834
Aihua SunState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Siu Kwan SzeDepartment of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada.ORCID 0000-0002-5652-1687
Chao TangCenter for Quantitative Biology, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.ORCID 0000-0003-1474-3705
Liujun TangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Ruijun TianDepartment of Chemistry, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0001-9521-5124
Juan Antonio VizcaínoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.ORCID 0000-0002-3905-4335
Chanjuan WangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Chen WangState Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Xiaowen WangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Xinxing WangDepartment of Nutrition, Tianjin Institute of Environmental and Operational Medicine, Tianjin, China.ORCID 0000-0003-1650-3297
Yan WangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Tobias WeissDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-5533-9429
Mathias WilhelmTechnical University of Munich, Freising, Germany.ORCID 0000-0002-9224-3258
Robert WinklerAdvanced Genomics Unit, Center for Research and Advanced Studies, Irapuato, Mexico.ORCID 0000-0001-6732-1958
Bernd WollscheidInstitute of Translational Medicine, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Limsoon WongDepartment of Computer Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-1241-5441
Linhai XieState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Wei XieSchool of Life Sciences, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing, China.ORCID 0000-0003-2126-3849
Tao XuGuangzhou National Laboratory, Guangzhou, China.ORCID 0000-0002-8260-9754
Tianhao XuInternational Academy of Phronesis Medicine (Guangdong), Guangdong, China.
Liying YanState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.ORCID 0000-0001-9572-9440
Jing YangGuangzhou National Laboratory, Guangzhou, China.
Xiao YangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.ORCID 0000-0002-0298-9831
John YatesThe Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-5267-1672
Tao YunChina Science and Technology Exchange Center, Beijing, China.
Qiwei ZhaiCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-9617-7403
Bing ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8676-2425
Hui ZhangDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8726-7098
Lihua ZhangState Key Laboratory of Medical Proteomics, National Chromatography R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.ORCID 0000-0003-3798-2047
Lingqiang ZhangState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Pingwen ZhangSchool of Mathematical Sciences, Peking University, Beijing, China.
Yukui ZhangState Key Laboratory of Medical Proteomics, National Chromatography R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
Yu Zi ZhengInternational Academy of Phronesis Medicine (Guangdong), Guangdong, China.
Qing ZhongProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia.ORCID 0000-0002-5340-301X
Yunping ZhuState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
π-HuB Consortium
Funding
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MMinistry of Science and Technology of the People’s Republic of ChinaNIEHS NIH HHS P30 ES017885
Abstract
The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called π-HuB (proteomic navigator of the human body). The aim of the π-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors.
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ProteomeProteomicsBig DataDatasets as TopicHumansInternational CooperationPrecision MedicineRisk AssessmentProteome
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