ArticleNature2025
Central control of dynamic gene circuits governs T cell rest and activation.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Integrated epigenetic and genetic programming of primary human T cells.Nature biotechnology · 2026Article
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- Article
- Technologies to measure and modulate protein subcellular localization.Nature reviews. Molecular cell biology · 2026Review
- Article
- Article
- FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry.Immunity · 2026Article
- A unified genetic perturbation language for human cellular programming.bioRxiv : the preprint server for biology · 2025Article
- Engineered natural killer cells for cancer therapy.Cancer cell · 2025Review
- Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics.Materials today. Bio · 2025Review
- The effects of mitochondrial damage and energy metabolism disorders on the progression of noise-induced deafness and its treatment.Head & face medicine · 2025Review
- T cells in cancer: mechanistic insights and therapeutic advances.Biomarker research · 2025Review
- Closing the loop: Teaching single-cell foundation models to learn from perturbations.bioRxiv : the preprint server for biology · 2025Article
- From CRISPR screens to circuits: identifying key regulators in T cell activation and state transitions.Signal transduction and targeted therapy · 2025Article
- Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq.bioRxiv : the preprint server for biology · 2025Article
- Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3.bioRxiv : the preprint server for biology · 2025Article
- Multi-physiology modeling of the immune system in the era of precision immunotherapy.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Maya M ArceGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Jennifer M UmhoeferGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0002-8563-9641
Nadia ArangQuantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.
Sivakanthan KasinathanGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0003-2218-6371
Jacob W FreimerGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0001-9239-2272
Zachary SteinhartGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Haolin ShenBiomedical Sciences graduate program, University of California, San Francisco, CA, USA.ORCID 0000-0003-1550-2831
Minh T N PhamDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Mineto OtaGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0003-4552-8573
Anika WadheraGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0009-0009-4694-6129
Rama DajaniGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Dmytro DorovskyiGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0009-0007-4297-2958
Yan Yi ChenGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Qi LiuGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Yuan ZhouQuantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.ORCID 0000-0002-1393-5476
Danielle L SwaneyQuantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.ORCID 0000-0001-6119-6084
Kirsten ObernierQuantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.ORCID 0000-0002-4025-1299
Brian R ShyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0001-9569-3708
Julia CarnevaleGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0001-9410-7148
Ansuman T SatpathyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID 0000-0002-5167-537X
Nevan J KroganQuantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.ORCID 0000-0003-4902-337X
Jonathan K PritchardDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8828-5236
Alexander MarsonGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. alex.marson@gladstone.ucsf.edu.
Funding
The Cancer Cell Map Initiative v2.0U54CA274502 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emma Lundberg · 2022 to 2026
$14.2MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MIntegration of genetic association mapping and functional data to elucidate genetic mechanisms of diseaseR01HG008140 · NHGRI · STANFORD UNIVERSITY · PI JONATHAN K PRITCHARD · 2016 to 2026
$7.3MTraining Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6MRestorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M4DN Interrogation of T Cell Exhaustion in CancerU01CA260852 · NCI · STANFORD UNIVERSITY · PI SATPATHY, ANSUMAN · 2020 to 2024
$2.6MTargeting SOCS1 and RASA2 to Engineer More Potent Adoptive T Cell Therapies for Cancer Treatment.K08CA252605 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CARNEVALE, JULIA C · 2020 to 2024
$1.3MNon-viral genome, epigenome, and transcriptome engineering for clinical CAR-T cell manufacturingK08CA273529 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian R Shy · 2022 to 2026
$1.2MBD FACSAria II Flow CytometerS10RR028962 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI CAVROIS, MARIELLE · 2011 to 2011
$544kAcquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencinS10OD010786 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COMAI, LUCA · 2012 to 2012
$311kNCATS NIH HHS L30 TR002983NCI NIH HHS K08 CA252605NCI NIH HHS K08 CA273529NCI NIH HHS U01 CA260852NCI NIH HHS U54 CA274502NCRR NIH HHS S10 RR028962NHGRI NIH HHS R01 HG008140NIAID NIH HHS T32 AI007334NIAMS NIH HHS T32 AR050942NIGMS NIH HHS T32 GM136547NIH HHS S10 OD010786
Abstract
The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks
Indexed as
CD4-Positive T-LymphocytesGene Expression RegulationGene Regulatory NetworksLymphocyte ActivationCRISPR-Cas SystemsHistonesHumansMediator ComplexMethylationProto-Oncogene Proteins c-mycSingle-Cell AnalysisT-LymphocytesT-Lymphocytes, RegulatoryHistonesMediator ComplexProto-Oncogene Proteins c-myc
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.