Evidence map›Paper›PMID 39663453›Full record

ArticleNature2025

Haematological setpoints are a stable and patient-specific deep phenotype.

Brody H Foy, Rachel Petherbridge, Maxwell T Roth, Cindy Zhang, Daniel C De Souza, Christopher Mow, Hasmukh R Patel, Chhaya H Patel, Samantha N Ho, Evie Lam and 5 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Trial
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  8. Article
  9. Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Brody H FoyCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. brodyfoy@uw.edu.ORCID 0000-0003-0127-7311
Rachel PetherbridgeCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3236-5587
Maxwell T RothCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Cindy ZhangDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0942-7321
Daniel C De SouzaCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-0247-511X
Christopher MowCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Hasmukh R PatelCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Chhaya H PatelCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Samantha N HoCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Evie LamCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
Camille E PoweDiabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Robert P HasserjianDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7753-0697
Konrad J KarczewskiProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2878-4671
Veronica TozzoCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.
John M HigginsCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. john_higgins@hms.harvard.edu.ORCID 0000-0002-9182-0076

Funding

Glycemic Observation Using A1C for Gestational Diabetes DiagnosisR01HD104756 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI John Matthew Higgins, Camille Elise Powe · 2022 to 2026
$3.5M
Towards optimizing diabetes management and diagnosis by personalizing HbA1c targetsR01DK123330 · NIDDK · UNIVERSITY OF CINCINNATI · PI COHEN, ROBERT MAYNARD · 2020 to 2024
$3.4M
NICHD NIH HHS R01 HD104756NIDDK NIH HHS R01 DK123330
6 · The paper itself

Abstract

The complete blood count (CBC) is an important screening tool for healthy adults and a common test at periodic exams. However, results are usually interpreted relative to one-size-fits-all reference intervals

Indexed as

Blood Cell CountPhenotypeAdultAgedFemaleHealthy VolunteersHumansMaleMiddle AgedPrecision MedicineReference ValuesRetrospective Studies

Identifiers

PMID39663453
PMCPMC12085991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.