Evidence map›Paper›PMID 39663447›Full record

ArticleNature2025

The mechanism of mRNA cap recognition.

Riley C Gentry, Nicholas A Ide, Victoria M Comunale, Erik W Hartwick, Colin D Kinz-Thompson, Ruben L Gonzalez

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Remodeling of mRNA by eIF4F in human translation initiation.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Target, silence, replace: a review on RNA-based drugs in modern medicine.Frontiers in cell and developmental biology · 2026
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Dynamics and Regulation of mRNA Cap Recognition by Human eIF4F.bioRxiv : the preprint server for biology · 2025
    Article
  19. Ribozyme-Catalyzed Site-Specific Labeling of RNA Using OAngewandte Chemie (International ed. in English) · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Riley C Gentry *Department of Biological Sciences, Columbia University, New York, NY, USA.
Nicholas A Ide *Department of Biological Sciences, Columbia University, New York, NY, USA.
Victoria M ComunaleDepartment of Chemistry, Columbia University, New York, NY, USA.
Erik W HartwickDepartment of Chemistry, Columbia University, New York, NY, USA.
Colin D Kinz-ThompsonDepartment of Chemistry, Columbia University, New York, NY, USA.
Ruben L GonzalezDepartment of Chemistry, Columbia University, New York, NY, USA. rlg2118@columbia.edu.ORCID 0000-0002-1344-5581

Funding

The Structural Dynamics of Translation InitiationR01GM084288 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2009 to 2022
$4.4M
The mechanism and regulation of mRNA recruitment during eukaryotic translation initiationR01CA277727 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Ruben L Gonzalez · 2023 to 2026
$1.3M
The Conformational Dynamics of eIF5B During Ribosomal Subunit JoiningF32GM139360 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HARTWICK, ERIK W · 2020 to 2022
$128k
NCI NIH HHS R01 CA277727NIGMS NIH HHS F32 GM139360NIGMS NIH HHS R01 GM084288
6 · The paper itself

Abstract

During translation initiation, mRNA molecules must be identified and activated for loading into a ribosome

Indexed as

Eukaryotic Initiation Factor-4FPeptide Chain Initiation, TranslationalRNA CapsRNA, MessengerAllosteric RegulationGuanosineHumansProtein BindingProtein SubunitsSingle Molecule ImagingStochastic Processes7-methylguanosineEukaryotic Initiation Factor-4FGuanosineProtein SubunitsRNA CapsRNA, Messenger

Identifiers

PMID39663447
PMCPMC12704497

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.