ReviewNature reviews. Neuroscience2025
Structurally informed models of directed brain connectivity.
Review in Nature reviews. Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Rs-fMRI reveals that taVNS improves cognitive and emotional function in mild cognitive impairment by reconfiguration of "sensory relay-salience-default" cross-network effective connectivity: a randomized, double-blind, sham-controlled trial.Frontiers in neurology · 2026Trial
- Multi-Scale Structural MRI Features Reveal Task-Based Functional Connectivity and Its Alterations in Psychiatric Disorders: A Collaborative Graph Attention Network Approach.Brain topography · 2026Article
- Bed nucleus of the stria terminalis connectivity during food cue and taste processing under stress.Nature communications · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Lifespan development of EEG alpha and aperiodic component sources is shaped by the connectome and axonal delays.National science review · 2026Article
- Functional, Structural, and AI-Based MRI Analysis: A Comprehensive Review of Recent Advances.Diagnostics (Basel, Switzerland) · 2025Review
- Structurally constrained functional connectivity reveals efficient visuomotor decision-making mechanisms in action video gamers.Scientific reports · 2025Article
- Review
- Structurally informed resting-state effective connectivity recapitulates cortical hierarchy.bioRxiv : the preprint server for biology · 2025Article
- Spectral imprint of structural embedding in effective connectivity.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how one brain region exerts influence over another in vivo is profoundly constrained by models used to infer or predict directed connectivity. Although such neural interactions rely on the anatomy of the brain, it remains unclear whether, at the macroscale, structural (or anatomical) connectivity provides useful constraints on models of directed connectivity. Here, we review the current state of research on this question, highlighting a key distinction between inference-based effective connectivity and prediction-based directed functional connectivity. We explore the methods via which structural connectivity has been integrated into directed connectivity models: through prior distributions, fixed parameters in state-space models and inputs to structure learning algorithms. Although the evidence suggests that integrating structural connectivity substantially improves directed connectivity models, assessments of reliability and out-of-sample validity are lacking. We conclude this Review with a strategy for future research that addresses current challenges and identifies opportunities for advancing the integration of structural and directed connectivity to ultimately improve understanding of the brain in health and disease.
Indexed as
Identifiers
39663407What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.