ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Deferred Cord Clamping With High Oxygen in Extremely Preterm Infants: A Randomized Clinical Trial.JAMA pediatrics · 2025Trial
- Practical interpretation of ILCOR and neonatal resuscitation program recommendations for initial oxygen concentration for neonatal resuscitation/stabilization.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Five-Minute Oxygen Saturation and Delivery Room Oxygen Requirements as Early Markers of Illness Severity in Preterm Infants ≤32 Weeks of Gestation: A Single-Centre Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Oxygen Saturation Target Achievement in Preterm Infants <32 Weeks' Gestation with 9Research square · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the relationship between 5-min oxygen saturation (SpO2) and outcomes in extremely preterm infants. STUDY
designThis cohort study included infants ≤28 weeks' gestation across nine hospitals from 2020 to 2022. Death and / or severe intraventricular hemorrhage (IVH) were compared between infants with 5-min SpO2 < 80% and 80-100% using Poisson regression models. Receiver Operating Characteristic (ROC) curve and optimal breakpoint analysis were used to estimate the optimal breakpoint of 5-min SpO2 in relation to outcomes.
resultOf 390 infants, 184 (47.2%) had 5-min SpO2 < 80%. A 5-min SpO2 < 80% was independently associated with increased risks of death and / or severe IVH, early death, and severe IVH. ROC analysis of 5-min SpO2 identified optimal breakpoint at 81-85%, above which no additional benefit in outcomes was observed.
conclusionOur findings support the current recommendation of 5-min SpO2 target of ≥80% for extremely preterm infants.
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