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ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Post-infectious central nervous system vasculitides in adults: an underdiagnosed and treatable disease : Part I. Overview.

Marialuisa Zedde, Rocco Quatrale, Vincenzo Andreone, Francesca Romana Pezzella, Giuseppe Micieli, Pietro Cortelli, Massimo Del Sette, Rosario Pascarella

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hemichorea as a primary manifestation of varicella-zoster virus neuroinfection in a child - a case report and review of literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Amendola 2, Reggio Emilia, 42122, Italy. zedde.marialuisa@ausl.re.it.ORCID http://orcid.org/0000-0001-7530-818X
Rocco QuatraleDipartimento Di Scienze Neurologiche, UOC Di Neurologia, Ospedale Dell'Angelo AULSS 3 Serenissima, Venice Mestre, Italy.ORCID https://orcid.org/0000-0002-2496-1709
Vincenzo AndreoneNeurology and Stroke Unit, A.O.R.N. Antonio Cardarelli, Napoli, Italy.ORCID https://orcid.org/0000-0002-9590-9414
Francesca Romana PezzellaHead, Neck and Neuroscience Department, San Camillo Forlanini Hospital, Rome, Italy.ORCID https://orcid.org/0000-0002-5902-2795
Giuseppe MicieliFormer Department of Emergency Neurology, IRCCS C. Mondino Foundation, Pavia, Italy.ORCID https://orcid.org/0000-0002-1746-478X
Pietro CortelliIRCCS Istituto Delle Scienze Neurologiche Di Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-3633-8818
Massimo Del SetteIRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID https://orcid.org/0009-0004-1594-2604
Rosario PascarellaNeuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Amendola 2, Reggio Emilia, 42122, Italy.ORCID https://orcid.org/0000-0002-0512-9298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe differential diagnosis of Primary Central Nervous System Angiitis (PACNS) is complex and includes several inflammatory and non-inflammatory conditions. Among the first ones, post-infectious CNS vasculitides represent a relevant topic and they are often underdiagnosed.

aimsThe main aim of this review is to summarize the clinical and neuroimaging features of post-infectious vasculitides, highlighting the diagnostic clues and the need to carefully consider them in the differential diagnosis of PACNS.

findingsSeveral infectious agents (viruses, bacteria, fungi and parasites) can be involved in documented post-infectious vasculitides, often with a pathological confirmation. Post-infectious vasculitides involve not only immunocompromised hosts but also immunocompetent people and the diagnosis might be complicated by the lack of close time relationship between infections and neuro-logical symptoms, as in Varicella Zoster Virus (VZV) related vasculopathy in adults. Several complications may occur, ranging from ischemic to hemorrhagic stroke, from arterial to venous thrombosis, from large to small vessel involvement, often simultaneously.

conclusionsPost-infectious vasculitides are caused by a broad spectrum of microorganisms and they should be carefully considered in the differential diagnosis of some neurological pictures and neuroradiologicals findings in immunocompetent adults too.

Indexed as

Vasculitis, Central Nervous SystemAdultDiagnosis, DifferentialHumansAngiitisAngiographyCNSCSFDSAHRVWIMRIMycotic aneurysmPACNSPost-infectiousStrokeSyphilisVZV

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.