Evidence map›Paper›PMID 39663272›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Prognostic role of quantitative pupillometry in traumatic brain injury: a scoping review.

Iman Kiani, Mohammadamin Parsaei, Hanie Karimi, Alireza Beikmarzehei, Shahnaz Fooladi Sarabi, Pegah Pezhdam, Mehranoosh Nouri Khoramabadian, Mojtaba Shahbazi, Maryam Masoudi, Hossein Sanjari Moghaddam

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iman KianiStudents' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadamin ParsaeiBreastfeeding Research Center, Family Health Research Institute, Tehran Univerity of Medical Sciences, Tehran, Iran.
Hanie KarimiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Alireza BeikmarzeheiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Shahnaz Fooladi SarabiAssistant Professor of Critical Care Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Pegah PezhdamSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehranoosh Nouri KhoramabadianShahid Rajaie Cardiovascular Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojtaba ShahbaziIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maryam MasoudiNeuroscience Institute, Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hossein Sanjari MoghaddamSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran. g.h.sanjarimoghaddam@gmail.com.ORCID http://orcid.org/0000-0001-7461-541X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraumatic brain injury (TBI) is a major cause of global mortality and disability, leading to primary and secondary brain injuries that can result in severe neurological, cognitive, and psychological impairments. Accurate and early prognosis of TBI outcomes is critical, particularly in assessing the risk of neurological decline, intracranial pressure (ICP) changes, and mortality.

objectiveThis systematic review aims to evaluate the prognostic value of quantitative pupillometry, particularly the Neurological Pupil Index (NPi), in predicting long-term outcomes in TBI patients.

methodsA systematic review was conducted following PRISMA guidelines, with the protocol registered on PROSPERO (CRD42023489079). Databases including PubMed, Scopus, and Embase were searched. Studies were included based on predefined inclusion criteria, focusing on the prognostic accuracy of automated pupillometry in TBI patients. Risk of bias was assessed using the Joanna Briggs Institute (JBI) tool, and evidence quality was evaluated using the Best-Evidence Synthesis approach.

resultsThirteen studies met the inclusion criteria, with sample sizes ranging from 36 to 2258 participants. The studies demonstrated a consistent association between lower NPi values and increased mortality, poorer functional outcomes, elevated ICP, and the need for emergency interventions. Despite variability in study design and sample sizes, strong evidence supported the use of NPi as a reliable prognostic tool in TBI management.

conclusionAutomated infrared pupillometry, particularly through NPi measurement, offers important prognostic value in TBI patients. Incorporating NPi into routine clinical practice could improve the accuracy of prognosis and enhance patient management. Future research should focus on standardizing measurement protocols and validating these findings in larger, more diverse cohorts.

Indexed as

Brain Injuries, TraumaticPupilHumansPrognosisReflex, PupillaryNeurological pupil indexQuantitative pupillometryTraumatic brain injury

Identifiers

PMID39663272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.