Evidence map›Paper›PMID 39663251›Full record

ArticleClinical oral investigations2024

A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.

Qianqian Zhang, Xinghan Li, Zhiyi Wang, Shijiao Shen, Junzhe Wang, Junyang Chen, Xiaoran Shi, Shichen Wang, Jun Cao, Yongqiang Deng and 2 more

Abstract read
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Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Exploration of a pain assessment tool on burning mouth syndrome.Journal of oral & facial pain and headache · 2025
    Article
4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Qianqian Zhang *Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Xinghan Li *Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Zhiyi WangSchool of Stomatology, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Shijiao ShenSchool of Stomatology, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Junzhe WangSchool of Stomatology, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Junyang ChenSchool of Medicine, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Xiaoran ShiSchool of Medicine, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Shichen WangZunyi Medical University, Zunyi, Guizhou, 563000, China.
Jun CaoDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
Yongqiang DengDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China.
He MengDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China. menghe@szu.edu.cn.
Lin MaDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen University, 1098 Xueyuan Avenue, Nanshan District, Shenzhen, Guangdong, 518055, China. malin2021@szu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515011945Medical Research Foundation of Guangdong Province A2024608
6 · The paper itself

Abstract

objectivesTo explore the potential role of oral bacteria in the pathogenesis of burning mouth syndrome (BMS). MATERIALS AND

methodsFifteen patients with BMS and 15 healthy controls were enrolled in this study. The relative abundance and diversity of salivary bacterial strains were analyzed using metagenomic DNA sequencing. The functionality of non-redundant genes was obtained by comparing the mmseqs2 with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMS relating salivary protein markers were detected using enzyme-linked immunosorbent assay (ELISA).

resultsPartial least-squares discriminant analysis (PLS-DA) revealed that the salivary bacterial profiles of the BMS group (mean age: 38.9 ± 2.2 years) differed significantly from those of the control group (mean age: 34.1 ± 2.3 years) in terms of the abundance of dominant phyla, classes, orders, families, genera and species. Functional analysis revealed distinct endocrine and immune functions in the BMS group. The salivary cortisol and α-amylase levels were significantly higher, and salivary interleukn-6 levels were significantly lower in the BMS group than in the control group. Species contribution analysis of endocrine and immune functions revealed that Streptococcus mitis was an important contributor to endocrine and immune functions in the BMS group.

conclusionsSalivary dysbiosis related to endocrine and immune functions may be a possible cause of BMS. CLINICAL RELEVANCE: These findings could assist in the diagnosis and therapy of BMS. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Burning Mouth SyndromeEnzyme-Linked Immunosorbent AssaySalivaAdultBiomarkersCase-Control StudiesDysbiosisFemaleHumansHydrocortisoneMalePilot ProjectsSalivary Proteins and PeptidesSequence Analysis, DNABiomarkersHydrocortisoneSalivary Proteins and PeptidesBurning mouth syndromeImmuneMetagenomicsMicrobial dysbiosisSaliva

Identifiers

PMID39663251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.