Evidence map›Paper›PMID 39663249›Full record

ArticlePsychopharmacology2025

Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.

Valeria Tarmati, Andrea Sepe, Alessandra Accoto, David Conversi, Daniela Laricchiuta, Anna Panuccio, Sonia Canterini, Maria Teresa Fiorenza, Simona Cabib, Cristina Orsini

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Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Valeria TarmatiDepartment of Psychology, Sapienza University of Rome, Rome, Italy. valeria.tarmati@uniroma1.it.ORCID http://orcid.org/0000-0002-5794-0314
Andrea SepePhD Program in Behavioral Neuroscience, Department of Psychology, Sapienza University of Rome, Rome, Italy.
Alessandra AccotoDepartment of Psychology, Sapienza University of Rome, Rome, Italy.
David ConversiDepartment of Psychology, Sapienza University of Rome, Rome, Italy.
Daniela LaricchiutaDepartment of Philosophy, Social Sciences & Education, University of Perugia, Perugia, Italy.
Anna PanuccioFondazione Santa Lucia IRCCS, Rome, Rome, Italy.
Sonia CanteriniDepartment of Psychology, Sapienza University of Rome, Rome, Italy.
Maria Teresa FiorenzaDepartment of Psychology, Sapienza University of Rome, Rome, Italy.
Simona CabibDepartment of Psychology, Sapienza University of Rome, Rome, Italy.
Cristina OrsiniDepartment of Psychology, Sapienza University of Rome, Rome, Italy.

Funding

Ateneo Sapienza RM1221816BB36E77
6 · The paper itself

Abstract

rationaleThe specific location of deviations from normative models of brain function varies considerably across individuals with the same diagnoses. However, as pathological processes are distributed across interconnected systems, this heterogeneity of individual brain deviations may also reveal similarities and differences between disorders. The paraventricular nucleus of the thalamus (PVT) is a potential switcher to various behavioral responses where functionally distinct cell types exist across its antero-posterior axis.

objectivesThis study aimed to test the hypothesis that genotype-dependent differences in the anterior and posterior PVT subregions (aPVT and pPVT) are involved in the Sign-tracking (ST) behavior expressed by C57BL/6J (C57) and DBA/2J (DBA) inbred mice.

methodsBased on previous findings, male mice of the two strains were tested at ten weeks of age. The density of c-Fos immunoreactivity along the antero-posterior axis of PVT was assessed following the expression of ST behavior. Selective excitotoxic lesions of the aPVT or the pPVT by the NMDA infusion were performed prior to development of ST behavior. Finally, the distribution of neuronal populations expressing the Drd2 and Gal genes (D2R + and Gal +) was measured by in situ hybridization (ISH).

resultsThe involvement of PVT subregions in ST behavior is strain-specific, as aPVT is crucial for ST acquisition in DBA mice while pPVT is crucial for C57 mice. Despite similar antero-posterior distribution of D2R + and Gal + neurons, density of D2R + neurons differentiate aPVT in C57 and DBA mice.

conclusionsThese genotype-dependent results offer valuable insights into the nuanced organization of brain networks and individual variability in behavioral responses.

Indexed as

Conditioning, ClassicalMidline Thalamic NucleiAnimalsBehavior, AnimalGenotypeMaleMiceMice, Inbred C57BLMice, Inbred DBAN-MethylaspartateProto-Oncogene Proteins c-fosReceptors, Dopamine D2Species SpecificityN-MethylaspartateProto-Oncogene Proteins c-fosReceptors, Dopamine D2Inbred strainIndividual differencesParaventricular nucleus of the thalamusPavlovian conditioned approachPersonalized modelsSign-tracking

Identifiers

PMID39663249

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