ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Evaluation of Spiral Ganglion Lesions by Electrophysiological Measures.Brain sciences · 2026Article
- Establishing reliable neural health measures in adult cochlear implant users.Frontiers in neuroscience · 2026Article
- Threshold-distance functions predict speech recognition with cochlear implants.Scientific reports · 2025Article
- A comparison of electrophysiological measures for characterizing the cochlear-implant electrode-neuron interface.JASA express letters · 2025Article
- The Failure Index as Marker of the Neural Health Profile in MED-EL CI Users: A Retrospective Analysis.Trends in hearingArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spiral ganglion neuron (SGN) degeneration is a candidate factor for reduced hearing outcomes in cochlear implant (CI) users. However, there is no procedure available to identify CI contacts close to focal SGN degeneration in human patients. In an animal model, we assessed the impact of focal SGN degeneration on electrical responsiveness and derived an electrophysiological marker for the presence, location, and size of such lesions. We introduced cochlear microlesions in 13 guinea pigs (six female) and recorded electrically evoked compound action potentials (eCAP) after 8-12 d. These were compared with recordings from controls (
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Registered trials
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